Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | F2R | P25116 | 1/20 | 0.34 |
| ▸ | RRM2 | P31350 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL951852 | 0.85 | KDM4E (0.59) | KDM4EL3MBTL1HRH3NPC1RAB9A | |
| SCHEMBL12431662 | 0.85 | KDM4E (0.59) | KDM4EL3MBTL1HRH3NPC1RAB9A | |
| SCHEMBL31261054 | 0.85 | KDM4E (0.59) | KDM4EL3MBTL1HRH3NPC1RAB9A | |
| SCHEMBL951851 | 0.85 | KDM4E (0.59) | KDM4EL3MBTL1HRH3NPC1RAB9A | |
| SCHEMBL15007 | 0.83 | KDM4E (0.61) | KDM4EL3MBTL1HRH3NPC1RAB9A | |
| SCHEMBL934192 | 0.81 | KDM4E (0.59) | KDM4EL3MBTL1HRH3NPC1RAB9A | |
| SCHEMBL13621098 | 0.79 | KDM4E (0.58) | KDM4EL3MBTL1HRH3NPC1RAB9A | |
| SCHEMBL19735046 | 0.79 | KDM4E (0.58) | KDM4EL3MBTL1HRH3NPC1RAB9A | |
| SCHEMBL6181463 | 0.79 | KDM4E (0.58) | KDM4EL3MBTL1HRH3NPC1RAB9A | |
| SCHEMBL9000467 | 0.78 | KDM4E (0.56) | KDM4EL3MBTL1HRH3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2471782-A1 | NOVEL SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME | Kowa Company, Ltd. (JP) | 2012-07-04 | — | — | EP | disclosed |
| US-20120122906-A1 | NOVEL SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME | KOWA COMPANY, LTD. (JP) | 2012-05-17 | — | — | US | disclosed |
| US-20120046308-A1 | NOVEL ALPHA-PHENOXYBENZENEACETIC ACID DERIVATIVE AND PHARMACEUTICAL PREPARATION COMPRISING SAME | KOWA COMPANY, LTD. (JP) | 2012-02-23 | — | — | US | disclosed |
| US-20090216024-A1 | Processes for making pioglitazone and compounds of the processes | ZHU JIE | 2009-08-27 | — | — | US | disclosed |
| US-7541470-B2 | Processes for making pioglitazone and compounds of the processes | SYNTHON IP INC. (US) | 2009-06-02 | — | — | US | disclosed |
| US-20070167629-A1 | Processes for making pioglitazone and compounds of the processes | SYNTHON IP INC. | 2007-07-19 | — | — | US | disclosed |
| EP-1716144-A2 | PROCESSES FOR MAKING PIOGLITAZONE AND COMPOUNDS OF THE PROCESSES | Synthon B.V. (NL) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080387-A2 | PROCESSES FOR MAKING PIOGLITAZONE AND COMPOUNDS OF THE PROCESSES | SYNTHON B.V. (NL) | 2005-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090216024-A1 | Processes for making pioglitazone and compounds of the processes | PDK4, PDK2, DPP4 | KDM4E 4654/4885L3MBTL1 4825/4885HRH3 4492/4885 |
| US-20120122906-A1 | NOVEL SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME | AGTR2, AGTR1, PPARA | KDM4E 4483/4885L3MBTL1 4709/4885HRH3 1472/4885 |
| US-20070167629-A1 | Processes for making pioglitazone and compounds of the processes | PDK4, PDK2, DPP4 | KDM4E 4654/4885L3MBTL1 4825/4885HRH3 4492/4885 |
| US-20120046308-A1 | NOVEL ALPHA-PHENOXYBENZENEACETIC ACID DERIVATIVE AND PHARMACEUTICAL PREPARATION COMPRISING SAME | PPARA, PPARG, PPARD | KDM4E 3100/4885L3MBTL1 3923/4885HRH3 819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.