Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 7/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29715575 | 0.80 | USP2 (0.42) | USP2SMN1; SMN2RECQLEPHX2GPR119 | |
| SCHEMBL20977338 | 0.80 | EPHX1 (0.45) | USP2SMN1; SMN2RECQLEPHX2GPR119 | |
| SCHEMBL20337474 | 0.79 | USP2 (0.41) | USP2SMN1; SMN2RECQLEPHX2GPR119 | |
| SCHEMBL30833164 | 0.79 | USP2 (0.41) | USP2SMN1; SMN2RECQLEPHX2GPR119 | |
| SCHEMBL18392380 | 0.79 | USP2 (0.41) | USP2SMN1; SMN2RECQLEPHX2GPR119 | |
| SCHEMBL18328440 | 0.79 | USP2 (0.41) | USP2SMN1; SMN2RECQLEPHX2GPR119 | |
| SCHEMBL30197470 | 0.79 | USP2 (0.41) | USP2SMN1; SMN2RECQLEPHX2GPR119 | |
| SCHEMBL20460932 | 0.79 | EPHX2 (0.43) | USP2SMN1; SMN2EPHX2GPR119EPHX1 | |
| SCHEMBL22799063 | 0.78 | USP2 (0.50) | USP2SMN1; SMN2RECQLEPHX2GPR119 | |
| SCHEMBL4693768 | 0.78 | USP2 (0.50) | USP2SMN1; SMN2RECQLEPHX2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468972-B1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2020-05-20 | — | — | EP | disclosed |
| WO-2017216706-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2017-12-21 | — | — | WO | disclosed |