Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 5/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20460932 | 0.80 | EPHX2 (0.43) | EPHX1EPHX2USP2SMN1; SMN2GPR119 | |
| SCHEMBL19736069 | 0.80 | USP2 (0.43) | EPHX1HPGDEPHX2USP2SMN1; SMN2 | |
| SCHEMBL18321889 | 0.79 | EPHX1 (0.43) | EPHX1HPGDEPHX2USP2SMN1; SMN2 | |
| SCHEMBL22015497 | 0.76 | EPHX2 (0.38) | EPHX1HPGDEPHX2USP2SMN1; SMN2 | |
| SCHEMBL29715656 | 0.76 | EPHX1 (0.42) | EPHX1HPGDEPHX2USP2SMN1; SMN2 | |
| SCHEMBL20951857 | 0.75 | EPHX1 (0.46) | EPHX1HPGDEPHX2USP2SMN1; SMN2 | |
| SCHEMBL24693758 | 0.75 | GPR119 (0.41) | EPHX1HPGDEPHX2GPR119NAMPT | |
| SCHEMBL16925210 | 0.75 | EPHX1 (0.41) | EPHX1HPGDEPHX2USP2SMN1; SMN2 | |
| SCHEMBL18392323 | 0.75 | EPHX1 (0.41) | EPHX1HPGDEPHX2USP2SMN1; SMN2 | |
| SCHEMBL18392450 | 0.75 | EPHX1 (0.41) | EPHX1HPGDEPHX2USP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310779-B1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2019-05-08 | — | — | EP | disclosed |