Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 17/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | HTR1D | P28221 | 3/20 | 0.46 |
| ▸ | HTR1B | P28222 | 3/20 | 0.46 |
| ▸ | HTR1F | P30939 | 3/20 | 0.46 |
| ▸ | HTR7 | P34969 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782718 | 0.84 | HTR6 (0.49) | HTR6DRD2HTR2ALMNASMN1; SMN2 | |
| SCHEMBL4783465 | 0.81 | HTR6 (0.51) | HTR6DRD2HTR2ALMNASMN1; SMN2 | |
| SCHEMBL3563612 | 0.74 | HTR6 (0.67) | HTR6DRD2LMNASMN1; SMN2HTR1A | |
| SCHEMBL12748649 | 0.73 | AKR1C3 (0.55) | HTR6DRD2LMNASMN1; SMN2HTR1A | |
| SCHEMBL4029770 | 0.72 | HTR6 (0.72) | HTR6DRD2HTR2ALMNAHTR1A | |
| SCHEMBL3624015 | 0.72 | HTR6 (0.64) | HTR6DRD2HTR2AHTR1AHTR1D | |
| SCHEMBL3410165 | 0.71 | HTR6 (0.54) | HTR6DRD2HTR2AHTR1AHTR1D | |
| SCHEMBL4782603 | 0.71 | BRD4 (0.43) | HTR6DRD2HTR2A | |
| SCHEMBL4784125 | 0.69 | HTR6 (0.48) | HTR6DRD2HTR2ALMNASMN1; SMN2 | |
| SCHEMBL3619795 | 0.69 | HTR6 (0.64) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155674-B1 | AMINOALKOXY ARYL SULFONAMIDE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LTD (IN) | 2011-06-22 | — | — | EP | disclosed |