Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 17/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | HTR1D | P28221 | 3/20 | 0.44 |
| ▸ | HTR1B | P28222 | 3/20 | 0.44 |
| ▸ | HTR1F | P30939 | 3/20 | 0.44 |
| ▸ | HTR7 | P34969 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782718 | 0.87 | HTR6 (0.49) | HTR6DRD2HTR1AHTR1DHTR1B | |
| SCHEMBL4784316 | 0.84 | HTR6 (0.46) | HTR6DRD2HTR2AMEN1KMT2A | |
| SCHEMBL4782095 | 0.82 | HTR6 (0.48) | HTR6HTR2AMEN1KMT2ALMNA | |
| SCHEMBL4782100 | 0.81 | HTR6 (0.47) | HTR6DRD2HTR1AHTR7HTR2A | |
| SCHEMBL1973755 | 0.81 | HTR6 (0.51) | HTR6DRD2HTR1AHTR1DHTR1B | |
| SCHEMBL4781303 | 0.81 | HTR6 (0.43) | HTR6DRD2HTR2AMEN1KMT2A | |
| SCHEMBL4782509 | 0.79 | MEN1 (0.61) | HTR6MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL4781382 | 0.78 | HTR6 (0.43) | HTR6DRD2HTR2AMEN1KMT2A | |
| SCHEMBL4781323 | 0.78 | HTR6 (0.43) | HTR6MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL22864566 | 0.76 | HTR6 (0.60) | HTR6DRD2HTR1AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |