Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.62 |
| ▸ | NPC1 | O15118 | 8/20 | 0.62 |
| ▸ | MEN1 | O00255 | 7/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.62 |
| ▸ | RAB9A | P51151 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 4/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.62 |
| ▸ | RELA | Q04206 | 2/20 | 0.62 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.54 |
| ▸ | RECQL | P46063 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19737716 | 0.92 | NPC1 (0.66) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL19737757 | 0.88 | MAPT (0.63) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL19737714 | 0.86 | LIMK1 (0.58) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL19737720 | 0.86 | LIMK1 (0.58) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL19737571 | 0.86 | LIMK1 (0.58) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL19737511 | 0.86 | LIMK1 (0.60) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL19737556 | 0.86 | LIMK1 (0.60) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL19737718 | 0.84 | MAPT (0.59) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL19737755 | 0.82 | LIMK1 (0.56) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL21051640 | 0.81 | MAPT (0.54) | MAPTNPC1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10689394-B2 | Thieno[2,3-b]pyridine derivative, quinoline derivative, and use thereof | THE UNIVERSITY OF TOKYO (JP) | 2020-06-23 | — | — | US | claimed |
| US-20190177336-A1 | THIENO[2,3-b]PYRIDINE DERIVATIVE AND QUINOLINE DERIVATIVE, AND USE THEREOF | THE UNIVERSITY OF TOKYO (JP) | 2019-06-13 | — | — | US | claimed |
| US-10689394-B2 | Thieno[2,3-b]pyridine derivative, quinoline derivative, and use thereof | THE UNIVERSITY OF TOKYO (JP) | 2020-06-23 | — | — | US | disclosed |
| US-10689394-B2 | Thieno[2,3-b]pyridine derivative, quinoline derivative, and use thereof | THE UNIVERSITY OF TOKYO (JP) | 2020-06-23 | — | — | US | disclosed |
| US-20190177336-A1 | THIENO[2,3-b]PYRIDINE DERIVATIVE AND QUINOLINE DERIVATIVE, AND USE THEREOF | THE UNIVERSITY OF TOKYO (JP) | 2019-06-13 | — | — | US | disclosed |
| US-20190177336-A1 | THIENO[2,3-b]PYRIDINE DERIVATIVE AND QUINOLINE DERIVATIVE, AND USE THEREOF | THE UNIVERSITY OF TOKYO (JP) | 2019-06-13 | — | — | US | disclosed |
| WO-2017217439-A1 | THIENO[2,3-b]PYRIDINE DERIVATIVE AND QUINOLINE DERIVATIVE, AND USE THEREOF | 国立大学法人東京大学 | 2017-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10689394-B2 | Thieno[2,3-b]pyridine derivative, quinoline derivative, and use thereof | BRD4, DRD4, TH | MAPT 3704/4885NPC1 2970/4885MEN1 2610/4885 |
| US-20190177336-A1 | THIENO[2,3-b]PYRIDINE DERIVATIVE AND QUINOLINE DERIVATIVE, AND USE THEREOF | DERL1, UBQLN1, ADRM1 | MAPT 882/4885NPC1 1712/4885MEN1 4286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.