Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
| ▸ | CA5A | P35218 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6683570 | 0.85 | MAPT (0.38) | MAPTHPGDSMN1; SMN2MGLLHSD17B10 | |
| SCHEMBL17788976 | 0.78 | KCNH2 (0.42) | MAPTHPGDSMN1; SMN2MGLLHSD17B10 | |
| SCHEMBL1975625 | 0.78 | MAPT (0.41) | MAPTHPGDSMN1; SMN2MGLLHSD17B10 | |
| SCHEMBL1975388 | 0.78 | MAPT (0.41) | MAPTHPGDSMN1; SMN2MGLLHSD17B10 | |
| SCHEMBL11124353 | 0.78 | HPGD (0.41) | MAPTHPGDSMN1; SMN2MGLLHSD17B10 | |
| SCHEMBL9327328 | 0.78 | MAPT (0.41) | MAPTHPGDSMN1; SMN2MGLLHSD17B10 | |
| SCHEMBL10453256 | 0.78 | KCNH2 (0.42) | MAPTHPGDSMN1; SMN2MGLLHSD17B10 | |
| SCHEMBL31333182 | 0.78 | MAPT (0.41) | MAPTHPGDSMN1; SMN2MGLLHSD17B10 | |
| SCHEMBL9329799 | 0.78 | MAPT (0.41) | MAPTHPGDSMN1; SMN2MGLLHSD17B10 | |
| SCHEMBL3070339 | 0.78 | MAPT (0.41) | MAPTHPGDSMN1; SMN2MGLLHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9932300-B2 | N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-04-03 | — | — | US | disclosed |
| US-20160318857-A1 | N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2016-11-03 | — | — | US | disclosed |
| US-9421211-B2 | N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-08-23 | — | — | US | disclosed |
| US-20120115915-A1 | N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-05-10 | — | — | US | disclosed |
| EP-1816183-B1 | DRIVING FORCE TRANSMITTING SYSTEM AND LUBRICANT COMPOSITION FOR THIS SYSTEM | NIPPON OIL CORP (JP) | 2011-06-22 | — | — | EP | disclosed |
| US-20080146474-A1 | Lubricant Composition and Driving Force Transmitting System Using Same | JTEKT CORPORATION (JP) | 2008-06-19 | — | — | US | disclosed |
| EP-1816183-A1 | LUBRICANT COMPOSITION AND DRIVING FORCE TRANSMITTING SYSTEM USING SAME | Nippon Oil Corporation (JP) | 2007-08-08 | — | — | EP | disclosed |
| US-20040204325-A1 | Transmission fluid compositions for automobiles | NIPPON OIL CORPORATION | 2004-10-14 | — | — | US | disclosed |
| US-20040192562-A1 | Lubricating oil composition | NIPPON OIL CORPORATION | 2004-09-30 | — | — | US | disclosed |
| US-4340705-A | PHOSPHORUS COMPONENT COORDINATION CATALYSTS | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1982-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318857-A1 | N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation | NSUN2, EIF2AK2, RNGTT | MAPT 1631/4885HPGD 1642/4885SMN1; SMN2 850/4885 |
| US-20120115915-A1 | N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION | NSUN2, EIF2AK2, RNGTT | MAPT 1631/4885HPGD 1642/4885SMN1; SMN2 850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.