Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.34 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | MTAP | Q13126 | 5/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | PRKDC | P78527 | 2/20 | 0.33 |
| ▸ | PI4KA | P42356 | 2/20 | 0.32 |
| ▸ | XDH | P47989 | 2/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.32 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25776394 | 0.81 | TRPA1 (0.51) | CHEK1RETTRPA1MAP3K7TAB1 | |
| SCHEMBL28057853 | 0.77 | TRPA1 (0.36) | CHEK1RETTRPA1MAP3K7TAB1 | |
| SCHEMBL28826847 | 0.75 | TRPA1 (0.35) | CHEK1RETTRPA1MAP3K7TAB1 | |
| SCHEMBL27975802 | 0.75 | MAP3K7 (0.41) | RETTRPA1MAP3K7TAB1MTAP | |
| SCHEMBL20125404 | 0.75 | JAK3 (0.43) | CHEK1RETTRPA1MAP3K7TAB1 | |
| SCHEMBL5805420 | 0.74 | RET (0.43) | CHEK1RETMAP3K7TAB1IRAK4 | |
| SCHEMBL30052782 | 0.72 | RET (0.42) | CHEK1RETTRPA1IRAK4PI4KA | |
| SCHEMBL6531144 | 0.72 | RET (0.42) | CHEK1RETTRPA1IRAK4PI4KA | |
| SCHEMBL23735452 | 0.71 | CHEK1 (0.48) | CHEK1RETTRPA1PI4KAXDH | |
| SCHEMBL868756 | 0.71 | RET (0.41) | CHEK1RETIRAK4PI4KAXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3472165-A1 | N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2019-04-24 | — | — | EP | disclosed |
| WO-2017220477-A1 | N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2017-12-28 | — | — | WO | disclosed |