Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.43 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.36 |
| ▸ | TAB1 | Q15750 | 4/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28826847 | 0.75 | TRPA1 (0.35) | MAP3K7TAB1RETTRPA1CHEK1 | |
| SCHEMBL27975802 | 0.75 | MAP3K7 (0.41) | MAP3K7TAB1RETTRPA1 | |
| SCHEMBL19743349 | 0.75 | CHEK1 (0.41) | MAP3K7TAB1RETTRPA1CHEK1 | |
| SCHEMBL25776394 | 0.75 | TRPA1 (0.51) | JAK3MAP3K7TAB1RETTRPA1 | |
| Toyocamycin Aglycone SCHEMBL7698538 | 0.71 | MAP3K7 (0.54) | MAP3K7TAB1LRRK2 | |
| SCHEMBL28057853 | 0.71 | TRPA1 (0.36) | MAP3K7TAB1RETTRPA1CHEK1 | |
| SCHEMBL23629980 | 0.70 | MTOR (0.38) | JAK3MAP3K7TAB1RETTRPA1 | |
| SCHEMBL16764642 | 0.70 | JAK3 (0.60) | JAK3PDPK1LRRK2 | |
| SCHEMBL16764641 | 0.70 | JAK3 (0.60) | JAK3PDPK1LRRK2 | |
| SCHEMBL12605469 | 0.69 | MAPK1 (0.43) | JAK3LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3318565-A1 | PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL AND PYRROLO[2,3-D]PYRIDINYL ACRYLAMIDES | Pfizer Inc (US) | 2018-05-09 | — | — | EP | disclosed |