SCHEMBL19743978

SCHEMBL19743978

CC(C)CNC(=O)c1cc(=O)c2ccccc2o1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.71
HTT P42858 2/20 0.61
RECQL P46063 1/20 0.60
POLB P06746 4/20 0.59
MEN1 O00255 3/20 0.59
KMT2A Q03164 3/20 0.59
MAPT P10636 2/20 0.59
ALDH1A1 P00352 2/20 0.59
SMN1; SMN2 Q16637 2/20 0.59
NPC1 O15118 1/20 0.59
RAB9A P51151 1/20 0.59
CSNK2A2 P19784 3/20 0.58
CSNK2B P67870 3/20 0.58
CSNK2A1 P68400 3/20 0.58
CSNK2A3 Q8NEV1 3/20 0.58
KDM4E B2RXH2 1/20 0.57
USP2 O75604 1/20 0.57
PTGS1 P23219 1/20 0.57
MAOA P21397 1/20 0.56
MAOB P27338 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21174942 0.84 AKR1B1 (0.59) LMNAPOLBKMT2AMAPTMAOA
SCHEMBL19744072 0.83 LMNA (1.00) LMNAHTTPOLBMEN1KMT2A
SCHEMBL27582528 0.82 LMNA (0.77) LMNAHTTRECQLPOLBMEN1
SCHEMBL5206502 0.82 LMNA (0.72) LMNAHTTRECQLPOLBMEN1
SCHEMBL5274120 0.81 LMNA (0.67) LMNAHTTRECQLPOLBMEN1
SCHEMBL8645195 0.81 LMNA (0.67) LMNAHTTRECQLPOLBMEN1
SCHEMBL5318759 0.79 LMNA (0.64) LMNAHTTRECQLPOLBMEN1
SCHEMBL21174969 0.78 LMNA (0.80) LMNAHTTPOLBKMT2AMAPT
SCHEMBL5321247 0.78 LMNA (0.63) LMNAHTTRECQLPOLBMEN1
SCHEMBL21174951 0.77 LMNA (0.66) LMNAHTTRECQLPOLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109641864-B Anti-infective agents 邓迪大学 2023-04-04 CN disclosed
US-11485720-B2 Anti-infective agents UNIVERSITY OF DUNDEE (GB) 2022-11-01 US disclosed
EP-3472141-B1 ANTI-INFECTIVE AGENTS UNIV DUNDEE (GB) 2022-10-05 EP disclosed
US-20210101877-A1 ANTI-INFECTIVE AGENTS UNIVERSITY OF DUNDEE (GB) 2021-04-08 US disclosed
US-20210101877-A1 ANTI-INFECTIVE AGENTS UNIVERSITY OF DUNDEE (GB) 2021-04-08 US disclosed
US-20190225592-A1 ANTI-INFECTIVE AGENTS UNIVERSITY OF DUNDEE (GB) 2019-07-25 US disclosed
US-20190225592-A1 ANTI-INFECTIVE AGENTS UNIVERSITY OF DUNDEE (GB) 2019-07-25 US disclosed
EP-3472141-A1 ANTI-INFECTIVE AGENTS University Of Dundee (GB) 2019-04-24 EP disclosed
WO-2017221002-A1 ANTI-INFECTIVE AGENTS UNIVERSITY OF DUNDEE (GB) 2017-12-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11485720-B2 Anti-infective agents C1R, RRS1, ARG1 LMNA 2536/4885HTT 4567/4885RECQL 40/4885
US-20210101877-A1 ANTI-INFECTIVE AGENTS C1R, RRS1, ARG1 LMNA 2536/4885HTT 4567/4885RECQL 40/4885
US-20190225592-A1 ANTI-INFECTIVE AGENTS C1R, ARG1, MSR1 LMNA 2610/4885HTT 4562/4885RECQL 41/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.