Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL19747588

NCCCCCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(O)C(F)(F)F

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 9/20 0.63
DDB1 Q16531 7/20 0.63
HDAC1 Q13547 7/20 0.62
HDAC2 Q92769 7/20 0.62
HDAC3 O15379 5/20 0.62
NCOR2 Q9Y618 5/20 0.62
STAT3 P40763 3/20 0.60
CA2 P00918 2/20 0.59
HDAC8 Q9BY41 1/20 0.53
TNF P01375 1/20 0.52
IL1B P01584 1/20 0.52
TBXA2R P21731 1/20 0.52
IKZF1 Q13422 1/20 0.52
IKZF3 Q9UKT9 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL31361483 1.00 CRBN (0.63) CRBNDDB1HDAC1HDAC2HDAC3
Trifluoroacetic Acid SCHEMBL31326918 1.00 CRBN (0.63) CRBNDDB1HDAC1HDAC2HDAC3
Trifluoroacetic Acid SCHEMBL31326912 1.00 CRBN (0.63) CRBNDDB1HDAC1HDAC2HDAC3
Trifluoroacetic Acid SCHEMBL22291385 1.00 CRBN (0.63) CRBNDDB1HDAC1HDAC2HDAC3
Trifluoroacetic Acid SCHEMBL31326916 1.00 CRBN (0.63) CRBNDDB1HDAC1HDAC2HDAC3
Trifluoroacetic Acid SCHEMBL28576091 0.99 CRBN (0.64) CRBNDDB1HDAC1HDAC2HDAC3
Trifluoroacetic Acid SCHEMBL31326913 0.97 CRBN (0.65) CRBNDDB1HDAC1HDAC2HDAC3
Trifluoroacetic Acid SCHEMBL17873751 0.93 CRBN (0.66) CRBNDDB1HDAC1HDAC2HDAC3
Trifluoroacetic Acid SCHEMBL29546227 0.93 CRBN (0.67) CRBNDDB1HDAC1HDAC2HDAC3
SCHEMBL23884378 0.92 CRBN (0.68) CRBNDDB1HDAC1HDAC2HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260008778-A1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC (US) 2026-01-08 US disclosed
US-12351579-B2 Compounds and uses thereof FOGHORN THERAPEUTICS INC. (US) 2025-07-08 US disclosed
US-20240067642-A1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC. 2024-02-29 US disclosed
US-20240002382-A1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC. 2024-01-04 US disclosed
US-20230416246-A1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC. 2023-12-28 US disclosed
US-20230331722-A1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC. 2023-10-19 US disclosed
US-20230142883-A1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC. 2023-05-11 US disclosed
US-20230066136-A1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC. 2023-03-02 US disclosed
US-11560381-B1 Compounds and uses thereof FOGHORN THERAPEUTICS INC. (US) 2023-01-24 US disclosed
US-11505560-B2 Heterobifunctional compounds with improved specificity DANA-FARBER CANCER INSTITUTE, INC. (US) 2022-11-22 US disclosed
US-11414416-B1 Compounds and uses thereof FOGHORN THERAPEUTICS INC. (US) 2022-08-16 US disclosed
EP-3917517-A1 COMPOUNDS AND USES THEREOF Foghorn Therapeutics Inc. (US) 2021-12-08 EP disclosed
US-20210130368-A1 HETEROBIFUNCTIONAL COMPOUNDS WITH IMPROVED SPECIFICITY DANA-FARBER CANCER INSTITUTE, INC. (US) 2021-05-06 US disclosed
WO-2020160198-A1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC. (US) 2020-08-06 WO disclosed
EP-3676268-A1 HETEROBIFUNCTIONAL COMPOUNDS WITH IMPROVED SPECIFICITYFOR THE BROMODOMAIN OF BRD4 Dana-Farber Cancer Institute, Inc. (US) 2020-07-08 EP disclosed
EP-3474900-A1 DEGRADATION OF BROMODOMAIN-CONTAINING PROTEIN 9 (BRD9) BY CONJUGATION OF BRD9 INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE Dana-Farber Cancer Institute, Inc. (US) 2019-05-01 EP disclosed
WO-2019079701-A1 HETEROBIFUNCTIONAL COMPOUNDS WITH IMPROVED SPECIFICITYFOR THE BROMODOMAIN OF BRD4 DANA-FARBER CANCER INSTITUTE, INC. (US) 2019-04-25 WO disclosed
WO-2017223452-A1 DEGRADATION OF BROMODOMAIN-CONTAINING PROTEIN 9 (BRD9) BY CONJUGATION OF BRD9 INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE DANA-FARBER CANCER INSTITUTE, INC. (US) 2017-12-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210130368-A1 HETEROBIFUNCTIONAL COMPOUNDS WITH IMPROVED SPECIFICITY MDM2, STUB1, UBE3C CRBN 113/4885DDB1 249/4885HDAC1 2077/4885
US-20230416246-A1 COMPOUNDS AND USES THEREOF VHL, TFEB, BECN1 CRBN 74/4885DDB1 706/4885HDAC1 342/4885
US-20230066136-A1 COMPOUNDS AND USES THEREOF VHL, TFEB, BECN1 CRBN 74/4885DDB1 706/4885HDAC1 342/4885
US-20230331722-A1 COMPOUNDS AND USES THEREOF VHL, TFEB, BECN1 CRBN 74/4885DDB1 706/4885HDAC1 342/4885
US-20240002382-A1 COMPOUNDS AND USES THEREOF VHL, TFEB, BECN1 CRBN 74/4885DDB1 706/4885HDAC1 342/4885
US-20230142883-A1 COMPOUNDS AND USES THEREOF VHL, TFEB, BECN1 CRBN 74/4885DDB1 706/4885HDAC1 342/4885
US-11414416-B1 Compounds and uses thereof VHL, TFEB, BECN1 CRBN 74/4885DDB1 706/4885HDAC1 342/4885
US-11505560-B2 Heterobifunctional compounds with improved specificity MDM2, STUB1, UBE3C CRBN 113/4885DDB1 249/4885HDAC1 2077/4885
US-11560381-B1 Compounds and uses thereof VHL, TFEB, BECN1 CRBN 74/4885DDB1 706/4885HDAC1 342/4885
US-20260008778-A1 COMPOUNDS AND USES THEREOF BRD9, BCL9L, BCL9 CRBN 7/4885DDB1 3044/4885HDAC1 467/4885
US-12351579-B2 Compounds and uses thereof VHL, TFEB, BECN1 CRBN 74/4885DDB1 706/4885HDAC1 342/4885
US-20240067642-A1 COMPOUNDS AND USES THEREOF VHL, TFEB, BECN1 CRBN 74/4885DDB1 706/4885HDAC1 342/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.