Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 5/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 6/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | MC5R | P33032 | 1/20 | 0.41 |
| ▸ | MC3R | P41968 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19750565 | 0.94 | MC4R (0.46) | CXCR4NCF1MC4RMC5RMC3R | |
| SCHEMBL16812990 | 0.92 | CHRM2 (0.50) | CHRM2MAOACXCR4NCF1ALDH1A1 | |
| SCHEMBL17832850 | 0.91 | CXCR4 (0.49) | CHRM2MAOACXCR4NCF1ALDH1A1 | |
| SCHEMBL16812995 | 0.87 | CXCR4 (0.49) | CHRM2CXCR4NCF1ALDH1A1ALOX15 | |
| SCHEMBL16812993 | 0.86 | MAPT (0.56) | CHRM2MAOACXCR4NCF1ALDH1A1 | |
| SCHEMBL18179874 | 0.84 | NCF1 (0.51) | CXCR4NCF1ALDH1A1ALOX15KDM4E | |
| SCHEMBL8735920 | 0.83 | HRH4 (0.60) | CHRM2CXCR4NCF1ALDH1A1ALOX15 | |
| SCHEMBL17832859 | 0.82 | NCF1 (0.50) | CXCR4NCF1ALDH1A1ALOX15KDM4E | |
| SCHEMBL18179876 | 0.82 | NCF1 (0.50) | NCF1ALDH1A1ALOX15KDM4EMEN1 | |
| SCHEMBL22736796 | 0.82 | MAOA (0.61) | CHRM2MAOAMC4RMC5RMC3R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230254-B1 | COMPOSITIONS AND METHODS FOR TREATING DISEASES AND CONDITIONS | UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION (US) | 2021-09-22 | — | — | EP | disclosed |
| US-10487076-B2 | Compositions and methods for treating diseases and conditions | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2019-11-26 | — | — | US | disclosed |
| US-20180134693-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASES AND CONDITIONS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-05-17 | — | — | US | disclosed |
| US-20180071232-A1 | COMPOSITIONS AND METHODS FOR TREATING RESPIRATORY INJURY OR DISEASE | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-03-15 | — | — | US | disclosed |
| US-9849098-B2 | Compositions and methods for treating respiratory injury or disease | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-12-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10487076-B2 | Compositions and methods for treating diseases and conditions | C1S, SLC10A1, C1R | CHRM2 77/4885MAOA 2740/4885CXCR4 219/4885 |
| US-20180071232-A1 | COMPOSITIONS AND METHODS FOR TREATING RESPIRATORY INJURY OR DISEASE | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, C9, C1S | CHRM2 647/4885MAOA 3038/4885CXCR4 144/4885 |
| US-20180134693-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASES AND CONDITIONS | C1S, SLC10A1, C1R | CHRM2 77/4885MAOA 2740/4885CXCR4 219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.