Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 3/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | SNRNP200 | O75643 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 2/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16477251 | 0.93 | CYP1A2 (0.41) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL1971288 | 0.93 | CYP1A2 (0.41) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL12554824 | 0.93 | CYP1A2 (0.41) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL1974580 | 0.93 | CYP1A2 (0.41) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL1971416 | 0.93 | CYP1A2 (0.41) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL1975512 | 0.87 | MAPK1 (0.40) | MAPTKMT2AHTR7SMN1; SMN2NPSR1 | |
| SCHEMBL1973774 | 0.79 | LMNA (0.38) | CYP1A2MAPTCYP2C19KMT2AHTR7 | |
| SCHEMBL1966160 | 0.77 | CYP1A2 (0.54) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL1975536 | 0.74 | MAPK1 (0.40) | MAPTKMT2AHTR7SMN1; SMN2NPSR1 | |
| SCHEMBL1973820 | 0.74 | MAPK1 (0.40) | MAPTKMT2AHTR7SMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130102604-A1 | NOVEL CYCLOPROPANE INDOLINONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2013-04-25 | — | — | US | disclosed |
| US-8354443-B2 | Cyclopropane indolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2013-01-15 | — | — | US | disclosed |
| US-20110144106-A1 | NOVEL CYCLOPROPANE INDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144106-A1 | NOVEL CYCLOPROPANE INDOLINONE DERIVATIVES | GPR119, CPT1A, IRS1 | CYP1A2 163/4885MAPT 3298/4885CYP2C19 748/4885 |
| US-20130102604-A1 | NOVEL CYCLOPROPANE INDOLINONE DERIVATIVES | GPR119, CPT1A, IRS1 | CYP1A2 157/4885MAPT 3247/4885CYP2C19 730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.