⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16910744 | 0.77 | — | — | |
| SCHEMBL23753088 | 0.67 | — | — | |
| SCHEMBL15270968 | 0.64 | SMN1; SMN2 (0.31) | — | |
| SCHEMBL290232 | 0.64 | — | — | |
| SCHEMBL1975196 | 0.60 | — | — | |
| SCHEMBL16911370 | 0.60 | ACHE (0.37) | — | |
| SCHEMBL12272890 | 0.58 | ADCY10 (0.35) | — | |
| SCHEMBL23026141 | 0.58 | LRRK2 (0.32) | — | |
| SCHEMBL24687264 | 0.54 | ADCY10 (0.33) | — | |
| SCHEMBL3414800 | 0.54 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160052920-A1 | BACE1 INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2016-02-25 | — | — | US | claimed |
| EP-2984086-A1 | BACE1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2016-02-17 | — | — | EP | claimed |
| US-9067926-B2 | Fluoromethyl-5,6-dihydro-4H-[1,3]OXAZINES | HOFFMANN-LA ROCHE INC. (US) | 2015-06-30 | — | — | US | claimed |
| US-20150031690-A1 | FLUOROMETHYL-5,6-DIHYDRO-4H-[1,3]OXAZINES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-01-29 | — | — | US | claimed |
| EP-2807155-A1 | FLUOROMETHYL-5,6-DIHYDRO-4H-[1,3]OXAZINES | F.HOFFMANN-LA ROCHE AG (CH) | 2014-12-03 | — | — | EP | claimed |
| WO-2014166906-A1 | BACE1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-10-16 | — | — | WO | claimed |
| WO-2013110622-A1 | FLUOROMETHYL-5,6-DIHYDRO-4H-[1,3]OXAZINES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-08-01 | — | — | WO | claimed |
| US-8389513-B2 | 2-amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)-phenyl]-amides | HOFFMANN-LA ROCHE INC. (US) | 2013-03-05 | — | — | US | claimed |
| EP-2509965-A1 | 2-AMINO-5, 5-DIFLUORO-5, 6-DIHYDRO-4H-OXAZINES AS BACE 1 AND/OR BACE 2 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-10-17 | — | — | EP | claimed |
| CN-102712609-A | 2-amino-5, 5-difluoro-5, 6-dihydro-4H-oxazines as BACE1 and/or BACE2 inhibitors | HOFFMANN LA ROCHE | 2012-10-03 | — | — | CN | claimed |
| WO-2011069934-A1 | 2-AMINO-5, 5-DIFLUORO-5, 6-DIHYDRO-4H-OXAZINES AS BACE 1 AND/OR BACE 2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | WO | claimed |
| US-20110144097-A1 | 2-AMINO-5,5-DIFLUORO-5,6-DIHYDRO-4H-[1,3]OXAZIN-4-YL)-PHENYL]-AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | US | claimed |
| CN-104066727-B | Methyl fluoride -5,6- dihydro -4H- [1,3] oxazines class | 霍夫曼-拉罗奇有限公司 | 2019-04-26 | — | — | CN | disclosed |
| EP-2807155-B1 | FLUOROMETHYL-5,6-DIHYDRO-4H-[1,3]OXAZINES | HOFFMANN LA ROCHE (CH) | 2017-04-12 | — | — | EP | disclosed |
| US-20160052920-A1 | BACE1 INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2016-02-25 | — | — | US | disclosed |
| EP-2984086-A1 | BACE1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2016-02-17 | — | — | EP | disclosed |
| CN-102712609-A | 2-amino-5, 5-difluoro-5, 6-dihydro-4H-oxazines as BACE1 and/or BACE2 inhibitors | HOFFMANN LA ROCHE | 2012-10-03 | — | — | CN | disclosed |
| US-20110312937-A1 | 2,5,6,7-TETRAHYDRO-[1,4]OXAZEPIN-3-YLAMINE OR 2,3,6,7-TETRAHYDRO-[1,4]OXAZEPIN-5-YLAMINE COMPOUNDS | SIENA BIOTECH S.P.A. (IT) | 2011-12-22 | — | — | US | disclosed |
| US-20110144097-A1 | 2-AMINO-5,5-DIFLUORO-5,6-DIHYDRO-4H-[1,3]OXAZIN-4-YL)-PHENYL]-AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | US | disclosed |
| WO-2011069934-A1 | 2-AMINO-5, 5-DIFLUORO-5, 6-DIHYDRO-4H-OXAZINES AS BACE 1 AND/OR BACE 2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | WO | disclosed |