Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.62 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ADH5 | P11766 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30317655 | 1.00 | CYP3A4 (0.62) | CYP3A4BAZ2BCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL600477 | 0.86 | CYP3A4 (0.61) | CYP3A4BAZ2BCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5280849 | 0.84 | CYP3A4 (0.60) | CYP3A4BAZ2BCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL17352303 | 0.84 | HTT (0.65) | CYP3A4BAZ2BCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL8297460 | 0.81 | CYP3A4 (0.56) | CYP3A4BAZ2BCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL26835756 | 0.80 | KCNJ1 (0.55) | CYP3A4BAZ2BCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5306190 | 0.80 | CYP3A4 (0.55) | CYP3A4BAZ2BCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL10757760 | 0.80 | CYP3A4 (0.55) | CYP3A4BAZ2BCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL7259823 | 0.79 | CYP3A4 (0.52) | CYP3A4BAZ2BCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL10469495 | 0.79 | CYP3A4 (0.54) | CYP3A4BAZ2BCYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117999075-A | Compounds and pharmaceutical compositions comprising inhibitors of amyloid peptide interaction with glycosaminoglycans, methods of treatment, and uses thereof | 吉斯莫治疗股份有限公司 | 2024-05-07 | — | — | CN | disclosed |
| EP-2725027-B1 | NOVEL COMPOUND WITH AMYLOID AFFINITY | NIHON MEDIPHYSICS CO LTD (JP) | 2017-03-01 | — | — | EP | disclosed |
| EP-2318006-B1 | NOVEL PYRROLE INHIBITORS OF S-NITROSOGLUTATHIONE REDUCTASE AS THERAPEUTIC AGENTS | NIVALIS THERAPEUTICS INC (US) | 2016-10-12 | — | — | EP | disclosed |
| EP-2318006-B1 | NOVEL PYRROLE INHIBITORS OF S-NITROSOGLUTATHIONE REDUCTASE AS THERAPEUTIC AGENTS | NIVALIS THERAPEUTICS INC (US) | 2016-10-12 | — | — | EP | disclosed |
| US-9211350-B2 | Compound with amyloid affinity | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2015-12-15 | — | — | US | disclosed |
| US-9211350-B2 | Compound with amyloid affinity | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2015-12-15 | — | — | US | disclosed |
| US-9138427-B2 | Pyrrole inhibitors of S-nitrosoglutathione reductase as therapeutic agents | NIVALIS THERAPEUTICS, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-9138427-B2 | Pyrrole inhibitors of S-nitrosoglutathione reductase as therapeutic agents | NIVALIS THERAPEUTICS, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-9138427-B2 | Pyrrole inhibitors of S-nitrosoglutathione reductase as therapeutic agents | NIVALIS THERAPEUTICS, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-20140194425-A1 | Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic Agents | N30 PHARMACEUTICALS, INC. (US) | 2014-07-10 | — | — | US | disclosed |
| US-20140121377-A1 | NOVEL COMPOUND WITH AMYLOID AFFINITY | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2014-05-01 | — | — | US | disclosed |
| EP-2725027-A1 | NOVEL COMPOUND WITH AMYLOID AFFINITY | Nihon Medi-Physics Co., Ltd. (JP) | 2014-04-30 | — | — | EP | disclosed |
| US-8691816-B2 | Pyrrole inhibitors of S-nitrosoglutathione reductase as therapeutic agents | N30 PHARMACEUTICALS, INC. (US) | 2014-04-08 | — | — | US | disclosed |
| US-8691816-B2 | Pyrrole inhibitors of S-nitrosoglutathione reductase as therapeutic agents | N30 PHARMACEUTICALS, INC. (US) | 2014-04-08 | — | — | US | disclosed |
| CN-103596950-A | Novel compound with amyloid affinity | NIHON MEDIPHYSICS CO LTD | 2014-02-19 | — | — | CN | disclosed |
| WO-2012176587-A1 | NOVEL COMPOUND WITH AMYLOID AFFINITY | 日本メジフィジックス株式会社 (JP) | 2012-12-27 | — | — | WO | disclosed |
| US-20110144110-A1 | Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic Agents | N30 PHARMACEUTICALS, LLC (US) | 2011-06-16 | — | — | US | disclosed |
| US-20110144110-A1 | Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic Agents | N30 PHARMACEUTICALS, LLC (US) | 2011-06-16 | — | — | US | disclosed |
| US-20110144110-A1 | Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic Agents | N30 PHARMACEUTICALS, LLC (US) | 2011-06-16 | — | — | US | disclosed |
| WO-2010019903-A1 | NOVEL PYRROLE INHIBITORS OF S-NITROSOGLUTATHIONE REDUCTASE AS THERAPEUTIC AGENTS | N30 PHARMACEUTICALS, LLC (US) | 2010-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140194425-A1 | Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic Agents | GSR, DHFR, GRHPR | CYP3A4 738/4885BAZ2B 2972/4885CYP1A2 495/4885 |
| US-20140121377-A1 | NOVEL COMPOUND WITH AMYLOID AFFINITY | APP, APBA1, BACE1 | CYP3A4 2017/4885BAZ2B 1206/4885CYP1A2 1797/4885 |
| US-20110144110-A1 | Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic Agents | GSR, DHFR, GRHPR | CYP3A4 738/4885BAZ2B 2972/4885CYP1A2 495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.