Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | USP7 | Q93009 | 3/20 | 0.35 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4633923 | 0.85 | ALDH1A1 (0.56) | ALDH1A1TSHRTDP1GRIN2DGRIN3B | |
| SCHEMBL29735720 | 0.83 | ALDH1A1 (0.54) | ALDH1A1TSHRTDP1GRIN2DGRIN3B | |
| SCHEMBL29301459 | 0.76 | ALDH1A1 (0.42) | ALDH1A1TSHRTDP1GRIN2DGRIN3B | |
| SCHEMBL31553067 | 0.76 | ALDH1A1 (0.42) | ALDH1A1TSHRTDP1GRIN2DGRIN3B | |
| SCHEMBL31481303 | 0.76 | ALDH1A1 (0.42) | ALDH1A1TSHRTDP1GRIN2DGRIN3B | |
| SCHEMBL10921245 | 0.75 | ALDH1A1 (0.40) | ALDH1A1TSHRTDP1LMNAHTT | |
| SCHEMBL30702012 | 0.72 | ALDH1A1 (0.42) | ALDH1A1TSHRTDP1LMNAHTT | |
| SCHEMBL14494900 | 0.72 | ALDH1A1 (0.42) | ALDH1A1TSHRTDP1LMNAHTT | |
| SCHEMBL2475362 | 0.72 | TSHR (0.41) | ALDH1A1TSHRTDP1LMNAMAPT | |
| SCHEMBL27672326 | 0.71 | HSP90AA1 (0.46) | ALDH1A1TSHRTDP1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180009805-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180009805-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | TAF1, TAF1L, TAF1B | ALDH1A1 2132/4885TSHR 1358/4885TDP1 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.