SCHEMBL19768149

SCHEMBL19768149

c1cc(-c2cnccn2)cc(-c2ccc3ccc4ccc(-c5ccc6c(c5)-c5cccc7cccc-6c57)nc4c3n2)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 2/20 0.37
FEN1 P39748 2/20 0.37
PIM2 Q9P1W9 4/20 0.37
SCN9A Q15858 1/20 0.36
SIRT2 Q8IXJ6 1/20 0.36
CYP11B1 P15538 2/20 0.36
CYP11B2 P19099 2/20 0.36
PIK3CD O00329 1/20 0.36
PIK3CA P42336 1/20 0.36
PIK3CB P42338 1/20 0.36
PI4KA P42356 1/20 0.36
PIK3CG P48736 1/20 0.36
PI4KB Q9UBF8 1/20 0.36
GRK6 P43250 1/20 0.35
PIM1 P11309 3/20 0.34
PIM3 Q86V86 1/20 0.34
DHFR P00374 1/20 0.34
CYP17A1 P05093 1/20 0.34
CYP19A1 P11511 1/20 0.34
ALDH1A1 P00352 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19768048 0.88 CYP11B2 (0.48) CYP11B1CYP11B2CYP17A1CYP19A1ALDH1A1
SCHEMBL19768154 0.87 MAPK1 (0.41) PIM2CYP11B1CYP11B2PIM1PIM3
SCHEMBL19768116 0.84 CYP11B1 (0.39) CYP11B1CYP11B2CYP17A1CYP19A1MAPK1
SCHEMBL19768109 0.84 TSHR (0.36) PIM2SIRT2PIM1CYP19A1ALDH1A1
SCHEMBL19768307 0.84 CLK1 (0.39) PIM2SIRT2CYP11B1CYP11B2PIM1
SCHEMBL19768259 0.84 NPC1 (0.40) PIM2SIRT2CYP11B1CYP11B2PIM1
SCHEMBL19768083 0.84 TNF (0.49) CYP11B1CYP11B2PIK3CDPIK3CBPIK3CG
SCHEMBL14500342 0.83 TSHR (0.46) ALDH1A1TSHRMAPK1HSD17B10TP53
SCHEMBL19768215 0.83 TGFBR1 (0.39) PIM2PIM1ALDH1A1TSHRMAPK1
SCHEMBL19768146 0.83 PIM2 (0.37) ALOX5APFEN1PIM2SCN9ASIRT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180019407-A1 PHENANTHROLINE DERIVATIVE, ELECTRONIC DEVICE CONTAINING SAME, LIGHT EMITTING ELEMENT, AND PHOTOELECTRIC CONVERSION ELEMENT TORAY INDUSTRIES, INC (JP) 2018-01-18 US disclosed
US-20180019407-A1 PHENANTHROLINE DERIVATIVE, ELECTRONIC DEVICE CONTAINING SAME, LIGHT EMITTING ELEMENT, AND PHOTOELECTRIC CONVERSION ELEMENT TORAY INDUSTRIES, INC (JP) 2018-01-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180019407-A1 PHENANTHROLINE DERIVATIVE, ELECTRONIC DEVICE CONTAINING SAME, LIGHT EMITTING ELEMENT, AND PHOTOELECTRIC CONVERSION ELEMENT SUN2, PAH, FARS2 ALOX5AP 4160/4885FEN1 3130/4885PIM2 1286/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.