SCHEMBL1976908

SCHEMBL1976908

CCN(C=O)C(O)[C@H]1O[C@@H](n2cnc3c(N)nc(Nc4ccc(CCC(=O)O)cc4)nc32)[C@H](O)[C@@H]1O

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 8/20 0.56
ADORA3 P0DMS8 4/20 0.56
ADORA1 P30542 4/20 0.56
KDM4E B2RXH2 3/20 0.56
ADORA2B P29275 3/20 0.56
KMT2A Q03164 3/20 0.56
ALOX15 P16050 2/20 0.56
HSD17B10 Q99714 2/20 0.56
MEN1 O00255 2/20 0.56
CYP2D6 P10635 2/20 0.56
CYP2C19 P33261 2/20 0.56
TSHR P16473 1/20 0.56
ALDH1A1 P00352 1/20 0.56
PMP22 Q01453 1/20 0.55
ATM Q13315 1/20 0.55
CYP1A2 P05177 2/20 0.50
THPO P40225 1/20 0.50
CYP2C9 P11712 1/20 0.50
BLM P54132 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1081737 0.91 ADORA2A (0.68) ADORA2AADORA3ADORA1KDM4EADORA2B
Hydrochloric Acid SCHEMBL6754869 0.91 ADORA2A (0.68) ADORA2AADORA3ADORA1KDM4EADORA2B
Hydrochloric Acid SCHEMBL2031971 0.90 ADORA2A (0.67) ADORA2AADORA3ADORA1KDM4EADORA2B
SCHEMBL2295172 0.84 ADORA2A (0.65) ADORA2AADORA3ADORA1KDM4EADORA2B
SCHEMBL724837 0.83 ADORA2A (0.58) ADORA2AADORA3ADORA1KDM4EADORA2B
SCHEMBL940189 0.81 ADORA2A (0.55) ADORA2AADORA3ADORA1KDM4EADORA2B
Hydrochloric Acid SCHEMBL9247444 0.81 ADORA2A (0.70) ADORA2AADORA3ADORA1KDM4EADORA2B
SCHEMBL8109955 0.79 ADORA2A (0.64) ADORA2AADORA3ADORA1ADORA2B
SCHEMBL6708382 0.78 ADORA2A (0.63) ADORA2AADORA3ADORA1KDM4EADORA2B
SCHEMBL258935 0.78 ADORA3 (0.59) ADORA2AADORA3ADORA1ADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110144027-A1 PHARMACEUTICAL COMPOSITIONS FOR PROMOTING WOUND HEALING KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. 2011-06-16 US disclosed
US-20070232561-A1 Pharmaceutical compositions for promoting wound healing KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. 2007-10-04 US disclosed
US-6303619-B1 BLOCKING VASOCONSTRICTIVE RESPONSE INDUCED THROUGH ADENOSINE ACTIVATION OF THE A.SUB.3 ADENOSINE RECEPTOR SUBTYPE, COMPRISING ADMINISTERING XANTHINE DERIVATIVE TO MAMMAL UNIVERSITY OF VIRGINIA 2001-10-16 US disclosed
US-6166181-A Human adenosine receptors MERCK & CO., INC. (US) 2000-12-26 US disclosed
US-5817760-A MAMMALIAN CELL MEMBRANES MERCK & CO., INC. (US) 1998-10-06 US disclosed
US-5780481-A Method for inhibiting activation of the human A3 adenosine receptor to treat asthma MERCK & CO., INC. (US) 1998-07-14 US disclosed
WO-1997033879-A1 COMPOUNDS AND METHODS FOR SELECTIVELY INHIBITING ACTIVATION OF THE HUMAN A3 ADENOSINE RECEPTOR MERCK & CO., INC. (US) 1997-09-18 WO disclosed
US-5646156-A ADMINISTERING XANTHINE DERIVATIVE AS ANTIINFLAMMATORY AGENT OR ANTIALLERGEN MERCK & CO., INC. (US) 1997-07-08 US disclosed
US-5599671-A GENETIC ENGINEERING MERCK & CO., INC. (US) 1997-02-04 US disclosed
WO-1995011681-A1 HUMAN ADENOSINE RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1995-05-04 WO disclosed