Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K8 | P41279 | 5/20 | 1.00 |
| ▸ | GSK3A | P49840 | 12/20 | 0.85 |
| ▸ | PIM1 | P11309 | 11/20 | 0.85 |
| ▸ | GSK3B | P49841 | 11/20 | 0.85 |
| ▸ | DYRK1A | Q13627 | 11/20 | 0.85 |
| ▸ | CDK2 | P24941 | 10/20 | 0.85 |
| ▸ | CSNK1D | P48730 | 10/20 | 0.85 |
| ▸ | CDK1 | P06493 | 9/20 | 0.85 |
| ▸ | CHEK2 | O96017 | 9/20 | 0.85 |
| ▸ | MAPK9 | P45984 | 9/20 | 0.85 |
| ▸ | KDR | P35968 | 9/20 | 0.85 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.85 |
| ▸ | CDK5 | Q00535 | 9/20 | 0.85 |
| ▸ | DAPK3 | O43293 | 8/20 | 0.85 |
| ▸ | PLK4 | O00444 | 8/20 | 0.85 |
| ▸ | LIMK1 | P53667 | 8/20 | 0.85 |
| ▸ | AURKA | O14965 | 8/20 | 0.85 |
| ▸ | CSNK2A1 | P68400 | 7/20 | 0.85 |
| ▸ | RPS6KA3 | P51812 | 7/20 | 0.85 |
| ▸ | PRKACA | P17612 | 7/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7056743 | 0.92 | GSK3A (1.00) | MAP3K8GSK3APIM1GSK3BDYRK1A | |
| SCHEMBL5555935 | 0.90 | MAP3K8 (1.00) | MAP3K8GSK3APIM1GSK3BDYRK1A | |
| SCHEMBL5550289 | 0.87 | MAP3K8 (0.77) | MAP3K8GSK3APIM1GSK3BDYRK1A | |
| SCHEMBL19769127 | 0.87 | MAP3K8 (0.81) | MAP3K8GSK3APIM1GSK3BDYRK1A | |
| SCHEMBL7056280 | 0.86 | MAP3K8 (0.76) | MAP3K8GSK3APIM1GSK3BDYRK1A | |
| SCHEMBL19780834 | 0.84 | PIM1 (0.80) | MAP3K8GSK3APIM1GSK3BDYRK1A | |
| SCHEMBL5550278 | 0.84 | MAP3K8 (0.72) | MAP3K8GSK3APIM1GSK3BDYRK1A | |
| SCHEMBL19769174 | 0.84 | PIM1 (0.74) | MAP3K8GSK3APIM1GSK3BDYRK1A | |
| SCHEMBL7056577 | 0.83 | GSK3A (0.78) | MAP3K8GSK3APIM1GSK3BDYRK1A | |
| SCHEMBL19769161 | 0.81 | PIM1 (0.79) | MAP3K8GSK3APIM1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180015077-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTION | NAKAMURA, ROBERT | 2018-01-18 | — | — | US | disclosed |
| US-20180015077-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTION | NAKAMURA, ROBERT | 2018-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180015077-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTION | CD4, CCR5, MMP8 | MAP3K8 3639/4885GSK3A 1892/4885PIM1 1098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.