Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 3/20 | 0.82 |
| ▸ | IKBKB | O14920 | 5/20 | 0.71 |
| ▸ | CDK8 | P49336 | 1/20 | 0.69 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 6/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | PIM1 | P11309 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4204752 | 0.92 | IKBKB (0.78) | LIMK1IKBKBCDK8CDK19MAPT | |
| SCHEMBL430576 | 0.90 | LIMK1 (1.00) | LIMK1IKBKBCDK8CDK19MAPT | |
| SCHEMBL19769213 | 0.89 | IKBKB (0.77) | LIMK1IKBKBCDK8CDK19MAPT | |
| SCHEMBL4198643 | 0.88 | MAPT (0.85) | LIMK1IKBKBCDK8CDK19MAPT | |
| SCHEMBL4193493 | 0.83 | IKBKB (1.00) | LIMK1IKBKBCDK8CDK19MAPT | |
| SCHEMBL12562468 | 0.83 | LIMK1 (0.72) | LIMK1IKBKBCDK8CDK19MAPT | |
| SCHEMBL19769223 | 0.83 | MAPT (0.93) | LIMK1IKBKBMAPTMEN1KMT2A | |
| SCHEMBL430610 | 0.82 | LIMK1 (0.74) | LIMK1IKBKBCDK8CDK19MAPT | |
| SCHEMBL431028 | 0.82 | CDK8 (1.00) | LIMK1IKBKBCDK8CDK19MAPT | |
| SCHEMBL12562463 | 0.81 | LIMK1 (0.84) | LIMK1IKBKBCDK8CDK19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180015077-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTION | NAKAMURA, ROBERT | 2018-01-18 | — | — | US | disclosed |
| US-20180015077-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTION | NAKAMURA, ROBERT | 2018-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180015077-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTION | CD4, CCR5, MMP8 | LIMK1 2745/4885IKBKB 1036/4885CDK8 1366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.