Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.34 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.34 |
| ▸ | TGM2 | P21980 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.30 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL2213085 | 0.98 | ALDH1A1 (0.41) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL19457855 | 0.91 | ALDH1A1 (0.44) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| Vinylsulfonic Acid SCHEMBL19717985 | 0.89 | ALDH1A1 (0.39) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| Sulfamate SCHEMBL28948557 | 0.89 | ALDH1A1 (0.39) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL26705 | 0.89 | — | — | |
| SCHEMBL35506 | 0.86 | ALDH1A1 (0.44) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| Ammonia Solution, Strong SCHEMBL1036558 | 0.86 | ALDH1A1 (0.44) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| Fluoride SCHEMBL21409814 | 0.86 | ALDH1A1 (0.44) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| Hydrochloric Acid SCHEMBL29176180 | 0.86 | ALDH1A1 (0.44) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL3468962 | 0.86 | ALDH1A1 (0.44) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9539366-B2 | Method for inducing regeneration of cartilage | NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) | 2017-01-10 | — | — | US | disclosed |
| EP-2143450-B1 | A hydrogel for use as bone filler inducing cartilage or cartilage tissue regeneration | UNIV HOKKAIDO NAT UNIV CORP (JP) | 2015-03-18 | — | — | EP | disclosed |
| CN-101557839-B | Bone filler for cartilage tissue regeneration treatment | UNIV HOKKAIDO NAT UNIV CORP | 2013-05-15 | — | — | CN | disclosed |
| US-20110257763-A1 | Method for Bone-filling Cartilage Tissue for Inducing Regeneration of the Cartilage | NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) | 2011-10-20 | — | — | US | disclosed |
| US-20110159099-A1 | BONE-FILLING TYPE AGENT FOR INDUCING CARTILAGE REGENERATION | NATIONAL UNIVERSITY CORPORATION, HOKKAIDO UNIVERSITY (JP) | 2011-06-30 | — | — | US | disclosed |
| EP-2335744-A1 | BONE-FILLING TYPE AGENT FOR INDUCING CARTILAGE REGENERATION | National University Corporation Hokkaido University (JP) | 2011-06-22 | — | — | EP | disclosed |
| EP-2143450-A1 | BONE FILLER FOR CARTILAGE TISSUE REGENERATION TREATMENT | National University Corporation Hokkaido University (JP) | 2010-01-13 | — | — | EP | disclosed |
| US-20100003328-A1 | BONE FILLER FOR CARTILAGE TISSUE REGENERATION TREATMENT | NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY | 2010-01-07 | — | — | US | disclosed |
| CN-101557839-A | Bone filler for cartilage tissue regeneration treatment | UNIV HOKKAIDO NAT UNIV CORP (JP) | 2009-10-14 | — | — | CN | disclosed |
| EP-0921432-A1 | Silver halide light-sensitive photographic comprising a phosphazene compound | KONICA CORPORATION (JP) | 1999-06-09 | — | — | EP | disclosed |