Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 5/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.40 |
| ▸ | ADK | P55263 | 1/20 | 0.38 |
| ▸ | RNASEL | Q05823 | 3/20 | 0.38 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.37 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10266135 | 0.84 | P2RX3 (0.47) | PRMT5WDR77ADKRNASEL | |
| SCHEMBL14313960 | 0.83 | PRMT5 (0.48) | PRMT5WDR77ADKMETTL3RAPGEF3 | |
| SCHEMBL14313963 | 0.83 | P2RX3 (0.49) | PRMT5WDR77RNASEL | |
| SCHEMBL19187629 | 0.74 | ADK (0.54) | PRMT5WDR77ADKMETTL3RAPGEF3 | |
| SCHEMBL14228171 | 0.74 | ADK (0.54) | PRMT5WDR77ADKMETTL3RAPGEF3 | |
| SCHEMBL10067814 | 0.74 | ADK (0.54) | PRMT5WDR77ADKMETTL3RAPGEF3 | |
| SCHEMBL20324592 | 0.74 | ADK (0.50) | PRMT5WDR77ADKRAPGEF3 | |
| SCHEMBL22524030 | 0.73 | PRMT5 (0.47) | PRMT5WDR77ADKMETTL3RAPGEF3 | |
| SCHEMBL19774719 | 0.72 | PRMT5 (0.35) | PRMT5WDR77ADKMETTL3 | |
| SCHEMBL22524009 | 0.72 | ADK (0.45) | PRMT5WDR77ADKMETTL3RAPGEF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928876-B1 | NUCLEOSIDE KINASE BYPASS COMPOSITIONS AND METHODS | MERCK SHARP & DOHME (US) | 2018-01-17 | — | — | EP | disclosed |