Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3248180 | 0.81 | DAO (0.43) | NPC1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL11361990 | 0.78 | LMNA (0.38) | MAPTNPC1ALDH1A1HSD17B10PTGS1 | |
| SCHEMBL20082234 | 0.77 | MAPT (0.34) | MAPTNPC1ALDH1A1GFERHSD17B10 | |
| SCHEMBL3247200 | 0.76 | HDAC3 (0.44) | MAPTNPC1ALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL17271417 | 0.73 | — | — | |
| SCHEMBL19775120 | 0.73 | PTGS1 (0.35) | MAPTNPC1ALDH1A1GFERHSD17B10 | |
| SCHEMBL19775149 | 0.72 | PTGS2 (0.32) | MAPTNPC1ALDH1A1GFERHSD17B10 | |
| SCHEMBL21230309 | 0.72 | PTGS2 (0.32) | MAPTNPC1ALDH1A1GFERHSD17B10 | |
| SCHEMBL19775385 | 0.71 | NPC1 (0.33) | MAPTNPC1ALDH1A1GFERHSD17B10 | |
| SCHEMBL14718383 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3311813-B1 | THERAPEUTIC ISOXAZOLE COMPOUNDS | DART NEUROSCIENCE CAYMAN LTD (KY) | 2019-08-07 | — | — | EP | disclosed |
| EP-2182809-B1 | THERAPEUTIC ISOXAZOLE COMPOUNDS | DART NEUROSCIENCE (CAYMAN) LTD (KY) | 2018-01-17 | — | — | EP | disclosed |