SCHEMBL19781058

SCHEMBL19781058

c1ccc2c(c1)Sc1cc3[nH]c4ccc5ccccc5c4c3cc1S2

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 9/20 0.45
CCND1 P24385 9/20 0.45
RAB9A P51151 3/20 0.36
KDM4E B2RXH2 2/20 0.36
SIRT2 Q8IXJ6 1/20 0.36
SIRT1 Q96EB6 1/20 0.36
ALDH1A1 P00352 4/20 0.36
HSD17B10 Q99714 4/20 0.36
LMNA P02545 1/20 0.36
CCNB2 O95067 1/20 0.35
CCNE2 O96020 1/20 0.35
CDK1 P06493 1/20 0.35
CCNB1 P14635 1/20 0.35
CCNE1 P24864 1/20 0.35
CDK2 P24941 1/20 0.35
CCNB3 Q8WWL7 1/20 0.35
AHR P35869 1/20 0.35
NPC1 O15118 2/20 0.35
KIF11 P52732 1/20 0.34
CYP2A6 P11509 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19450069 0.85 CDK4 (0.52) CDK4CCND1RAB9AKDM4ESIRT2
SCHEMBL12219467 0.83 CDK4 (0.56) CDK4CCND1RAB9AKDM4ESIRT2
SCHEMBL12219480 0.81 CDK4 (0.54) CDK4CCND1RAB9AKDM4ESIRT2
SCHEMBL12219477 0.81 CDK4 (0.54) CDK4CCND1RAB9AKDM4ESIRT2
SCHEMBL29405999 0.80 CDK4 (0.53) CDK4CCND1RAB9AKDM4ESIRT2
SCHEMBL12219456 0.80 CDK4 (0.53) CDK4CCND1RAB9AKDM4ESIRT2
SCHEMBL16048023 0.80 CDK4 (0.53) CDK4CCND1RAB9AKDM4ESIRT2
SCHEMBL19781006 0.78 MAPT (0.42) RAB9AKDM4EALDH1A1HSD17B10LMNA
SCHEMBL19781205 0.78 KIF11 (0.57) CDK4CCND1RAB9AKDM4ESIRT2
SCHEMBL18185294 0.77 ALDH1A1 (0.52) CDK4CCND1RAB9AKDM4ESIRT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018012763-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME 주식회사 두산 2018-01-18 WO disclosed