SCHEMBL19781258

SCHEMBL19781258

CCCCc1ccc(Nc2ccc(NC3CC(C)(C)NC(C)(C)C3)cc2)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.63
MEN1 O00255 4/20 0.63
KMT2A Q03164 4/20 0.63
ALDH1A1 P00352 3/20 0.63
LMNA P02545 3/20 0.63
ALOX12 P18054 2/20 0.63
L3MBTL1 Q9Y468 2/20 0.63
PKM P14618 1/20 0.63
ALOX15 P16050 1/20 0.63
RAD52 P43351 1/20 0.63
GFER P55789 1/20 0.63
GAA P10253 3/20 0.41
HPGD P15428 3/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
MAPK1 P28482 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
DRD2 P14416 1/20 0.39
DRD3 P35462 1/20 0.39
KCNH2 Q12809 1/20 0.39
KDM4E B2RXH2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10780921 0.79 ALDH1A1 (0.77) MAPTMEN1KMT2AALDH1A1LMNA
SCHEMBL19780825 0.78 ALDH1A1 (0.77) MAPTMEN1KMT2AALDH1A1LMNA
SCHEMBL8738952 0.78 ALDH1A1 (1.00) MAPTMEN1KMT2AALDH1A1LMNA
SCHEMBL19782763 0.77 ALDH1A1 (0.74) MAPTMEN1KMT2AALDH1A1LMNA
SCHEMBL1902409 0.76 EPHX1 (0.50) MAPTALDH1A1LMNAHPGDSMN1; SMN2
SCHEMBL14127779 0.75 HPGD (0.58) MAPTMEN1KMT2AALDH1A1LMNA
SCHEMBL48879 0.75 HPGD (0.58) MAPTMEN1KMT2AALDH1A1LMNA
SCHEMBL1498933 0.73 ALDH1A1 (0.49) MAPTMEN1KMT2AALDH1A1LMNA
SCHEMBL1907517 0.72 EPHX1 (0.60) MAPTALDH1A1LMNAPKMHPGD
SCHEMBL20357747 0.71 ALDH1A1 (0.66) MAPTMEN1KMT2AALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3484983-B1 SYNERGISTIC LUBRICATING OIL COMPOSITION CONTAINING MIXTURE OF ANTIOXIDANTS CHEVRON ORONITE CO (US) 2020-05-27 EP disclosed
US-20180016512-A1 Synergistic Lubricating Oil Composition Containing Mixture of Antioxidants CHEVRON ORONITE COMPANY LLC 2018-01-18 US disclosed
WO-2018013181-A1 SYNERGISTIC LUBRICATING OIL COMPOSITION CONTAINING MIXTURE OF ANTIOXIDANTS CHEVRON ORONITE COMPANY LLC (US) 2018-01-18 WO disclosed