SCHEMBL8738952

SCHEMBL8738952

CC1(C)CC(Nc2ccc(Nc3ccccc3)cc2)CC(C)(C)N1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 1.00
KMT2A Q03164 3/20 1.00
ALOX15 P16050 2/20 1.00
ALOX12 P18054 2/20 1.00
L3MBTL1 Q9Y468 2/20 1.00
MEN1 O00255 1/20 1.00
LMNA P02545 1/20 1.00
MAPT P10636 1/20 1.00
PKM P14618 1/20 1.00
RAD52 P43351 1/20 1.00
GFER P55789 1/20 1.00
KDM1A O60341 1/20 0.49
POLB P06746 1/20 0.46
EZH2 Q15910 3/20 0.44
GAA P10253 1/20 0.44
HTT P42858 1/20 0.43
TSHR P16473 3/20 0.43
HSD17B10 Q99714 2/20 0.43
PTGS1 P23219 1/20 0.43
SLC6A2 P23975 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9380274 0.93 KMT2A (0.87) ALDH1A1KMT2AALOX15ALOX12L3MBTL1
SCHEMBL10780921 0.88 ALDH1A1 (0.77) ALDH1A1KMT2AALOX15ALOX12L3MBTL1
SCHEMBL19780825 0.87 ALDH1A1 (0.77) ALDH1A1KMT2AALOX15ALOX12L3MBTL1
SCHEMBL19782763 0.85 ALDH1A1 (0.74) ALDH1A1KMT2AALOX15ALOX12L3MBTL1
SCHEMBL809441 0.81 ALDH1A1 (0.69) ALDH1A1KMT2AALOX15ALOX12L3MBTL1
SCHEMBL20357747 0.79 ALDH1A1 (0.66) ALDH1A1KMT2AALOX15ALOX12L3MBTL1
SCHEMBL19780860 0.79 MAPT (0.65) ALDH1A1KMT2AALOX15ALOX12L3MBTL1
SCHEMBL19781258 0.78 MAPT (0.63) ALDH1A1KMT2AALOX15ALOX12L3MBTL1
SCHEMBL8739251 0.78 EZH2 (0.76) ALDH1A1KMT2AALOX15ALOX12L3MBTL1
SCHEMBL9372093 0.76 KMT2A (0.61) ALDH1A1KMT2AALOX15ALOX12L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260083724-A1 COMPOUNDS TARGETING PAX3::FOXO1 FUSION PROTEIN GEORGETOWN UNIVERSITY (US) 2026-03-26 US disclosed
EP-3484983-B1 SYNERGISTIC LUBRICATING OIL COMPOSITION CONTAINING MIXTURE OF ANTIOXIDANTS CHEVRON ORONITE CO (US) 2020-05-27 EP disclosed
US-20180016512-A1 Synergistic Lubricating Oil Composition Containing Mixture of Antioxidants CHEVRON ORONITE COMPANY LLC 2018-01-18 US disclosed
WO-2018013181-A1 SYNERGISTIC LUBRICATING OIL COMPOSITION CONTAINING MIXTURE OF ANTIOXIDANTS CHEVRON ORONITE COMPANY LLC (US) 2018-01-18 WO disclosed
US-9504729-B2 Antiangiogenic small molecules and methods of use THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2016-11-29 US disclosed
US-9504729-B2 Antiangiogenic small molecules and methods of use THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2016-11-29 US disclosed
US-20160030508-A1 ANTIANGIOGENIC SMALL MOLECULES AND METHODS OF USE THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) 2016-02-04 US disclosed
US-20160030508-A1 ANTIANGIOGENIC SMALL MOLECULES AND METHODS OF USE THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) 2016-02-04 US disclosed
US-9186365-B2 Antiangiogenic small molecules and methods of use THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2015-11-17 US disclosed
US-9186365-B2 Antiangiogenic small molecules and methods of use THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2015-11-17 US disclosed
US-20120129775-A1 ANTIANGIOGENIC SMALL MOLECULES AND METHODS OF USE THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2012-05-24 US disclosed
US-20120129775-A1 ANTIANGIOGENIC SMALL MOLECULES AND METHODS OF USE THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2012-05-24 US disclosed
WO-2011014825-A2 ANTIANGIOGENIC SMALL MOLECULES AND METHODS OF USE THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2011-02-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160030508-A1 ANTIANGIOGENIC SMALL MOLECULES AND METHODS OF USE VEGFA, FLT4, KDR ALDH1A1 1615/4885KMT2A 3811/4885ALOX15 3009/4885
US-20260083724-A1 COMPOUNDS TARGETING PAX3::FOXO1 FUSION PROTEIN PAX3, FOXO1, PAXBP1 ALDH1A1 2739/4885KMT2A 545/4885ALOX15 4788/4885
US-20120129775-A1 ANTIANGIOGENIC SMALL MOLECULES AND METHODS OF USE VEGFA, FLT4, KDR ALDH1A1 1615/4885KMT2A 3811/4885ALOX15 3009/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.