Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.47 |
| ▸ | PTAFR | P25105 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TET3 | O43151 | 1/20 | 0.44 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.44 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | WNT1 | P04628 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 2/20 | 0.43 |
| ▸ | INSR | P06213 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979456 | 0.98 | PTAFR (0.47) | TLR7TLR9TLR8NR4A1PTAFR | |
| SCHEMBL1981277 | 0.95 | WNT1 (0.49) | TLR7TLR9TLR8NR4A1PTAFR | |
| SCHEMBL1981315 | 0.92 | PTAFR (0.47) | TLR7TLR9PTAFRALDH1A1WNT1 | |
| SCHEMBL1983761 | 0.90 | BRAF (0.47) | TLR7TLR9PTAFRALDH1A1L3MBTL1 | |
| SCHEMBL12597227 | 0.89 | PTAFR (0.42) | TLR7TLR9TLR8NR4A1PTAFR | |
| SCHEMBL1981803 | 0.89 | MTNR1A (0.45) | TLR7TLR9TLR8PTAFRALDH1A1 | |
| SCHEMBL12597223 | 0.89 | TLR7 (0.42) | TLR7TLR9TLR8PTAFRALDH1A1 | |
| SCHEMBL1981005 | 0.89 | FYN (0.47) | TLR7TLR9TLR8NR4A1FYN | |
| SCHEMBL1982709 | 0.88 | TLR8 (0.48) | TLR7TLR9TLR8NR4A1WNT1 | |
| SCHEMBL12598112 | 0.88 | TLR7 (0.45) | TLR7TLR9TLR8PTAFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | claimed |
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |