Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21922075 | 0.84 | CSNK1A1 (0.40) | CSNK1A1CLK4CYP11B1CYP11B2ADORA2A | |
| SCHEMBL29768800 | 0.77 | CSNK1A1 (0.36) | CSNK1A1CLK4CYP11B1CYP11B2ADORA2A | |
| SCHEMBL19779692 | 0.74 | TSHR (0.37) | CSNK1A1CLK4CYP11B1CYP11B2 | |
| SCHEMBL18125583 | 0.74 | CYP11B2 (0.45) | CYP11B1CYP11B2 | |
| SCHEMBL1999359 | 0.71 | HTT (0.34) | CSNK1A1CLK4CYP11B1CYP11B2 | |
| SCHEMBL19779742 | 0.69 | CYP2E1 (0.37) | CSNK1A1CLK4CYP11B1CYP11B2 | |
| SCHEMBL27294895 | 0.69 | KDM4E (0.46) | CLK4CYP11B1CYP11B2 | |
| SCHEMBL22096833 | 0.69 | CYP11B1 (0.32) | CSNK1A1CLK4CYP11B1CYP11B2 | |
| SCHEMBL19768943 | 0.69 | KDM5A (0.36) | CSNK1A1CLK4CYP11B1CYP11B2 | |
| SCHEMBL21883804 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013676-A1 | SOMATOSTATIN MODULATORS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. (US) | 2018-01-18 | — | — | WO | disclosed |