Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.31 |
| ▸ | TYR | P14679 | 1/20 | 0.31 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17494744 | 0.84 | TDP1 (0.41) | BACE1TRIM24TYRTRIM33 | |
| SCHEMBL30219107 | 0.80 | BACE1 (0.56) | BACE1TRIM24TRIM33TACR1 | |
| SCHEMBL2082920 | 0.80 | BACE1 (0.56) | BACE1TRIM24TRIM33TACR1 | |
| SCHEMBL18149538 | 0.79 | CYP3A4 (0.37) | BACE1 | |
| SCHEMBL25284529 | 0.79 | BACE1 (0.36) | BACE1 | |
| SCHEMBL21163340 | 0.78 | ALDH1A1 (0.39) | BACE1 | |
| SCHEMBL9125186 | 0.78 | BACE1 (0.38) | BACE1 | |
| SCHEMBL23462893 | 0.78 | IDO1 (0.44) | BACE1 | |
| SCHEMBL16880571 | 0.77 | BACE1 (0.39) | BACE1TACR1 | |
| SCHEMBL18071006 | 0.77 | GAA (0.39) | BACE1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190292176-A1 | BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS | BISTOL MYERS SQUIBB COMPANY (US) | 2019-09-26 | — | — | US | disclosed |
| WO-2018013774-A1 | BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190292176-A1 | BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS | F2, F2RL3, PF4 | BACE1 1192/4885TRIM24 4734/4885TYR 477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.