Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | TP53 | P04637 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.61 |
| ▸ | CCR1 | P32246 | 3/20 | 0.61 |
| ▸ | CCR5 | P51681 | 3/20 | 0.61 |
| ▸ | CCR8 | P51685 | 3/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.61 |
| ▸ | ALPL | P05186 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.61 |
| ▸ | ALPI | P09923 | 1/20 | 0.61 |
| ▸ | ALPG | P10696 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | METAP1 | P53582 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30608756 | 1.00 | KDM4E (0.61) | KDM4ESMN1; SMN2TP53LMNATDP1 | |
| SCHEMBL20919383 | 0.90 | KDM4E (0.68) | KDM4ESMN1; SMN2TP53LMNATDP1 | |
| Hydrochloric Acid SCHEMBL4902758 | 0.85 | SMN1; SMN2 (0.61) | KDM4ESMN1; SMN2TP53LMNATDP1 | |
| SCHEMBL20919346 | 0.82 | KMT2A (0.57) | KDM4ESMN1; SMN2TP53LMNATDP1 | |
| SCHEMBL2819228 | 0.82 | CDK4 (0.54) | KDM4ESMN1; SMN2TP53LMNATDP1 | |
| SCHEMBL3133015 | 0.81 | KDM4E (0.47) | KDM4ESMN1; SMN2TP53LMNATDP1 | |
| SCHEMBL10958587 | 0.79 | KDM4E (0.63) | KDM4ESMN1; SMN2TP53LMNATDP1 | |
| SCHEMBL4902982 | 0.78 | SMN1; SMN2 (0.52) | KDM4ESMN1; SMN2TP53LMNATDP1 | |
| SCHEMBL3951276 | 0.78 | MEN1 (0.67) | SMN1; SMN2ALOX15NPC1RAB9AKMT2A | |
| SCHEMBL29544002 | 0.78 | MEN1 (0.67) | SMN1; SMN2ALOX15NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116751195-A | Bipyridine compound, pharmaceutically acceptable salt thereof, preparation method and application | 杭州科兴生物化工有限公司 | 2023-09-15 | — | — | CN | disclosed |
| US-10913734-B2 | Substituted aminothiazoles | BARUCH S. BLUMBERG INSTITUTE | 2021-02-09 | — | — | US | disclosed |
| US-10913734-B2 | Substituted aminothiazoles | BARUCH S. BLUMBERG INSTITUTE | 2021-02-09 | — | — | US | disclosed |
| US-20190241552-A1 | SUBSTITUTED AMINOTHIAZOLES | BARUCH S. BLUMBERG INSTITUTE | 2019-08-08 | — | — | US | disclosed |
| US-20190241552-A1 | SUBSTITUTED AMINOTHIAZOLES | BARUCH S. BLUMBERG INSTITUTE | 2019-08-08 | — | — | US | disclosed |
| EP-3481810-A1 | SUBSTITUTED AMINOTHIAZOLES | Baruch S. Blumberg Institute (US) | 2019-05-15 | — | — | EP | disclosed |
| WO-2018013508-A1 | SUBSTITUTED AMINOTHIAZOLES | BARUCH S. BLUMBERG INSTITUTE (US) | 2018-01-18 | — | — | WO | disclosed |
| WO-2018013508-A1 | SUBSTITUTED AMINOTHIAZOLES | BARUCH S. BLUMBERG INSTITUTE (US) | 2018-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10913734-B2 | Substituted aminothiazoles | ABAT, AADAT, BCAT1 | KDM4E 1505/4885SMN1; SMN2 1331/4885TP53 159/4885 |
| US-20190241552-A1 | SUBSTITUTED AMINOTHIAZOLES | ABAT, AADAT, BCAT1 | KDM4E 1505/4885SMN1; SMN2 1331/4885TP53 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.