Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | F13A1 | P00488 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | TGM1 | P22735 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18493958 | 1.00 | GPR119 (0.52) | GPR119CHRNB2CHRNA4HSD11B1MAPT | |
| SCHEMBL15249212 | 1.00 | GPR119 (0.52) | GPR119CHRNB2CHRNA4HSD11B1MAPT | |
| SCHEMBL18573434 | 1.00 | GPR119 (0.52) | GPR119CHRNB2CHRNA4HSD11B1MAPT | |
| SCHEMBL29437362 | 1.00 | GPR119 (0.52) | GPR119CHRNB2CHRNA4HSD11B1MAPT | |
| SCHEMBL2299598 | 1.00 | GPR119 (0.52) | GPR119CHRNB2CHRNA4HSD11B1MAPT | |
| SCHEMBL2301999 | 0.94 | GPR119 (0.47) | GPR119CHRNB2CHRNA4HSD11B1MAPT | |
| SCHEMBL5034069 | 0.84 | CHRNB2 (0.61) | CHRNB2CHRNA4MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL5034082 | 0.84 | CHRNB2 (0.61) | CHRNB2CHRNA4MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL2723631 | 0.84 | CHRNB2 (0.61) | CHRNB2CHRNA4MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL15034386 | 0.84 | GPR119 (0.53) | GPR119CHRNB2CHRNA4HSD11B1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180015096-A1 | HIGHLY ACTIVE ANTI-NEOPLASTIC AND ANTI-PROLIFERATIVE AGENTS | G1 THERAPEUTICS, INC. (US) | 2018-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180015096-A1 | HIGHLY ACTIVE ANTI-NEOPLASTIC AND ANTI-PROLIFERATIVE AGENTS | MKI67, PCNA, HRAS | GPR119 4239/4885CHRNB2 4835/4885CHRNA4 4865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.