Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 12/20 | 0.33 |
| ▸ | JAK2 | O60674 | 11/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.32 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | RARB | P10826 | 1/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21220057 | 1.00 | NTRK1 (0.33) | NTRK1JAK2KDM4EALDH1A1LMNA | |
| SCHEMBL22591858 | 0.90 | ACKR3 (0.34) | NTRK1JAK2KDM4EALDH1A1LMNA | |
| SCHEMBL18313304 | 0.90 | ACKR3 (0.34) | NTRK1JAK2KDM4EALDH1A1LMNA | |
| SCHEMBL19783935 | 0.88 | ALDH1A1 (0.36) | NTRK1JAK2KDM4EALDH1A1LMNA | |
| SCHEMBL19783937 | 0.87 | KMT2A (0.37) | NTRK1JAK2KDM4EALDH1A1LMNA | |
| SCHEMBL19783954 | 0.87 | TDO2 (0.34) | NTRK1JAK2KDM4EALDH1A1LMNA | |
| SCHEMBL18313309 | 0.86 | ACKR3 (0.32) | NTRK1JAK2KDM4EALDH1A1LMNA | |
| SCHEMBL21220079 | 0.86 | KDM4E (0.33) | NTRK1JAK2KDM4EALDH1A1LMNA | |
| SCHEMBL21220054 | 0.86 | KDM4E (0.33) | NTRK1JAK2KDM4EALDH1A1LMNA | |
| SCHEMBL19783961 | 0.86 | EPHA2 (0.32) | NTRK1JAK2KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3481823-B1 | 7-SUBSTITUTED 1-PYRIDYL-NAPHTHYRIDINE-3-CARBOXYLIC ACID AMIDES AND USE THEREOF | Bayer Pharma AG (DE) | 2020-10-28 | — | — | EP | disclosed |
| WO-2018011017-A1 | 7-SUBSTITUTED 1-PYRIDYL-NAPHTHYRIDINE-3-CARBOXYLIC ACID AMIDES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-01-18 | — | — | WO | disclosed |