Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.43 |
| ▸ | BCHE | P06276 | 3/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22839864 | 0.83 | ACHE (0.43) | ACHEBCHEMAOBDRD2DRD4 | |
| SCHEMBL22839870 | 0.79 | BCHE (0.41) | ACHEBCHEMAOB | |
| SCHEMBL19782569 | 0.79 | DRD2 (0.46) | ACHEBCHEMAOBDRD2DRD4 | |
| SCHEMBL18557682 | 0.76 | ACHE (0.48) | ACHEBCHEMAOBDRD2DRD4 | |
| SCHEMBL22839858 | 0.75 | CHRM3 (0.45) | ACHEBCHEMAOBDRD2DRD4 | |
| SCHEMBL19782485 | 0.75 | DRD2 (0.44) | ACHEBCHEMAOBDRD2DRD4 | |
| SCHEMBL19782475 | 0.74 | BCHE (0.58) | ACHEBCHEMAOBDRD2DRD4 | |
| SCHEMBL19784066 | 0.74 | CHRM3 (0.46) | ACHEBCHEMAOBDRD2DRD4 | |
| SCHEMBL18557686 | 0.74 | KDM4E (0.47) | ACHEBCHEMAOBDRD2DRD4 | |
| SCHEMBL24404488 | 0.73 | BCHE (0.53) | ACHEBCHEMAOBDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018011090-A1 | HYDROXYQUINOLINONE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-01-18 | — | — | WO | disclosed |