Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | ELANE | P08246 | 7/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | RARA | P10276 | 1/20 | 0.49 |
| ▸ | RARB | P10826 | 1/20 | 0.49 |
| ▸ | RARG | P13631 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | EP300 | Q09472 | 1/20 | 0.46 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363569 | 0.88 | F2RL3 (1.00) | F2RL3KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL29403731 | 0.88 | F2RL3 (1.00) | F2RL3KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL27512690 | 0.86 | F2RL3 (0.80) | F2RL3KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL23551968 | 0.86 | F2RL3 (0.69) | F2RL3KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL4478363 | 0.84 | F2RL3 (0.74) | F2RL3KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL17322911 | 0.78 | HSD17B10 (0.64) | F2RL3KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL15631894 | 0.77 | ALDH1A1 (0.76) | F2RL3KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL7488323 | 0.76 | F2RL3 (0.78) | F2RL3KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL6352575 | 0.73 | KDM4E (0.59) | F2RL3KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL31426904 | 0.73 | KDM4E (0.59) | F2RL3KDM4EALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484881-B1 | BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2020-04-29 | — | — | EP | disclosed |
| WO-2018013770-A1 | BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-01-18 | — | — | WO | disclosed |