Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 6/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HAT1 | O14929 | 2/20 | 0.36 |
| ▸ | EP300 | Q09472 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1982173 | 0.91 | CHEK1 (0.45) | CHEK1PIM1MAP4K4ACHEPIM3 | |
| SCHEMBL12597208 | 0.87 | CHEK1 (0.42) | CHEK1PIM1MAP4K4ACHEPIM3 | |
| SCHEMBL1983422 | 0.86 | CHEK1 (0.42) | CHEK1PIM1MAP4K4ACHEPIM3 | |
| SCHEMBL1983392 | 0.81 | PIM1 (0.45) | CHEK1PIM1ACHEPIM3PIM2 | |
| SCHEMBL1982365 | 0.80 | NEK1 (0.39) | CHEK1PIM1ACHEPIM3PIM2 | |
| SCHEMBL1984109 | 0.78 | CHEK1 (0.48) | CHEK1PIM1MAP4K4ACHEPIM3 | |
| SCHEMBL12597220 | 0.77 | TLR7 (0.41) | MAP4K1CCNA2CDK2TTKTLR8 | |
| SCHEMBL11908677 | 0.77 | CHEK1 (0.47) | CHEK1PIM1MAP4K4ACHEPIM3 | |
| SCHEMBL1979521 | 0.77 | PIM1 (0.50) | CHEK1PIM1ACHEPIM3PIM2 | |
| SCHEMBL12597221 | 0.75 | GSK3B (0.40) | CHEK1PIM1PLAUMAP4K1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |