Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 12/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | PRKCH | P24723 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979339 | 0.90 | CHUK (0.51) | PIM1PIM3PIM2MAPTCHUK | |
| SCHEMBL1984089 | 0.85 | PIM1 (0.44) | PIM1PIM3PIM2MAPTCHUK | |
| SCHEMBL1979707 | 0.83 | PIM1 (0.44) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL1979521 | 0.81 | PIM1 (0.50) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL1978484 | 0.81 | CHEK1 (0.42) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL12597376 | 0.79 | PIM1 (0.48) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL1982964 | 0.77 | MAP4K1 (0.54) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL1982365 | 0.77 | NEK1 (0.39) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL1979541 | 0.76 | MAP4K1 (0.49) | PIM1PIM3PIM2MAPTMAP4K1 | |
| SCHEMBL12597612 | 0.75 | PIM1 (0.44) | PIM1PIM3PIM2MAPTCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |