Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDX3X | O00571 | 3/20 | 0.65 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17978487 | 0.89 | DDX3X (0.63) | DDX3XKDREIF2AK2SMN1; SMN2LMNA | |
| SCHEMBL19784943 | 0.87 | DDX3X (0.77) | DDX3XKDREIF2AK2SMN1; SMN2POLB | |
| SCHEMBL17978456 | 0.80 | DDX3X (0.75) | DDX3XKDRPOLBLMNANPC1 | |
| SCHEMBL17978453 | 0.78 | DDX3X (1.00) | DDX3XKDREIF2AK2POLBNPC1 | |
| SCHEMBL19784959 | 0.75 | DDX3X (0.93) | DDX3XKDREIF2AK2NPC1RAB9A | |
| SCHEMBL19784743 | 0.71 | DDX3X (0.61) | DDX3XLMNATRPV1MAPTKDM4E | |
| SCHEMBL27788947 | 0.68 | USP2 (0.61) | SMN1; SMN2LMNAS1PR2S1PR1S1PR3 | |
| SCHEMBL19403810 | 0.67 | TRPV1 (0.42) | DDX3XKDRLMNANPC1RAB9A | |
| SCHEMBL17669987 | 0.67 | KDR (1.00) | DDX3XKDREIF2AK2AURKAMAPK13 | |
| SCHEMBL17978449 | 0.65 | LMNA (0.71) | DDX3XSMN1; SMN2LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180016243-A1 | HUMAN HELICASE DDX3 INHIBITORS AS THERAPEUTIC AGENTS | AZIENDA OSPEDALIERA UNIVERSITARIA SENESE (IT) | 2018-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180016243-A1 | HUMAN HELICASE DDX3 INHIBITORS AS THERAPEUTIC AGENTS | DDX3X, DDX39B, DDX1 | DDX3X 1/4885KDR 4472/4885EIF2AK2 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.