Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.34 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19784974 | 0.86 | MAP4K4 (0.34) | MAP4K4GPR119SETD7HSD11B1FAAH | |
| SCHEMBL21260292 | 0.78 | GPR119 (0.37) | MAP4K4GPR119SETD7HSD11B1HDAC1 | |
| SCHEMBL19785152 | 0.77 | CALCA (0.32) | MAP4K4GPR119SETD7ALDH1A1 | |
| SCHEMBL19632326 | 0.76 | GPR119 (0.38) | MAP4K4GPR119SETD7HSD11B1HDAC1 | |
| SCHEMBL21058315 | 0.76 | GPR119 (0.38) | MAP4K4GPR119SETD7HSD11B1HDAC1 | |
| SCHEMBL17936825 | 0.74 | HDAC1 (0.39) | MAP4K4GPR119SETD7HSD11B1HDAC1 | |
| SCHEMBL20691685 | 0.74 | MEN1 (0.39) | MAP4K4GPR119SETD7HSD11B1HDAC1 | |
| SCHEMBL19632319 | 0.74 | GPR119 (0.37) | MAP4K4GPR119SETD7HSD11B1HDAC1 | |
| SCHEMBL22615358 | 0.74 | MEN1 (0.39) | MAP4K4GPR119SETD7HSD11B1HDAC1 | |
| SCHEMBL17925539 | 0.74 | HDAC1 (0.39) | MAP4K4GPR119SETD7HSD11B1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018011163-A1 | 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE AND 6,7-DIHYDRO-4H-TRIAZOLO[1,5-A]PYRAZINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 2018-01-18 | — | — | WO | disclosed |