Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | PPIB | P23284 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1978480 | 0.79 | KDM4E (0.47) | MAOBKDM4EMEN1KMT2ACYP3A4 | |
| SCHEMBL1978518 | 0.78 | AKT1 (0.44) | MAOBKDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1978759 | 0.74 | MEN1 (0.36) | MAOBAPPMEN1KMT2ACMA1 | |
| SCHEMBL10237816 | 0.74 | AKT1 (0.54) | MAOBKDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1982797 | 0.73 | MEN1 (0.39) | MAOBMEN1KMT2ACMA1MDM2 | |
| SCHEMBL8514081 | 0.73 | AKT1 (0.56) | MAOBKDM4EKMT2ASMN1; SMN2AKT1 | |
| SCHEMBL1981849 | 0.72 | AKT1 (0.42) | MAOBKDM4EKLK7KMT2ASMN1; SMN2 | |
| SCHEMBL8512880 | 0.72 | AKT1 (0.47) | MAOBKDM4EKLK7KMT2ASMN1; SMN2 | |
| SCHEMBL1982412 | 0.71 | BACE1 (0.46) | MEN1KMT2AMAPTMDM2 | |
| SCHEMBL874004 | 0.71 | AKT1 (0.60) | MAOBKDM4EKMT2ASMN1; SMN2AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | disclosed |