Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1982797 | 0.85 | MEN1 (0.39) | MEN1KMT2AMAOBMDM2CMA1 | |
| SCHEMBL1982412 | 0.83 | BACE1 (0.46) | MEN1KMT2AMDM2PTPN1 | |
| SCHEMBL1978029 | 0.82 | CYP3A4 (0.37) | MEN1KMT2A | |
| SCHEMBL1979002 | 0.82 | AKR1B1 (0.45) | — | |
| SCHEMBL1977904 | 0.76 | AKR1B1 (0.35) | — | |
| SCHEMBL1821638 | 0.75 | CTSD (0.47) | — | |
| SCHEMBL1978508 | 0.74 | MAOB (0.44) | MEN1KMT2AMAOBMDM2CMA1 | |
| SCHEMBL10576683 | 0.73 | PDE7A (0.44) | — | |
| SCHEMBL1819232 | 0.72 | MEN1 (0.45) | MEN1KMT2A | |
| SCHEMBL1820315 | 0.72 | AKR1B1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | disclosed |