Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1978518 | 0.79 | AKT1 (0.44) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL1978508 | 0.79 | MAOB (0.44) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL10237816 | 0.74 | AKT1 (0.54) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL1978029 | 0.74 | CYP3A4 (0.37) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL8514081 | 0.73 | AKT1 (0.56) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL1983002 | 0.72 | BACE1 (0.40) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL874004 | 0.72 | AKT1 (0.60) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL1821389 | 0.71 | MAPT (0.71) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL1981849 | 0.70 | AKT1 (0.42) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL6837032 | 0.70 | SIGMAR1 (0.51) | KDM4EALDH1A1HPGDAKT1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | disclosed |