Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20460883 | 1.00 | GPR119 (0.46) | GPR119HPGDUSP2SMN1; SMN2EPHX2 | |
| SCHEMBL24439202 | 0.91 | CYP11B2 (0.44) | GPR119HPGDUSP2SMN1; SMN2EPHX2 | |
| SCHEMBL29673993 | 0.91 | CYP11B2 (0.44) | GPR119HPGDUSP2SMN1; SMN2EPHX2 | |
| SCHEMBL19839242 | 0.91 | CYP11B2 (0.44) | GPR119HPGDUSP2SMN1; SMN2EPHX2 | |
| SCHEMBL485056 | 0.91 | GPR119 (0.50) | GPR119HPGDUSP2SMN1; SMN2EPHX2 | |
| SCHEMBL1474868 | 0.89 | USP2 (0.49) | GPR119HPGDUSP2SMN1; SMN2EPHX2 | |
| SCHEMBL22747737 | 0.86 | CHRM2 (0.44) | GPR119HPGDUSP2SMN1; SMN2EPHX2 | |
| SCHEMBL22915089 | 0.86 | CHRM2 (0.44) | GPR119HPGDUSP2SMN1; SMN2EPHX2 | |
| SCHEMBL29427120 | 0.86 | CHRM2 (0.44) | GPR119HPGDUSP2SMN1; SMN2EPHX2 | |
| SCHEMBL20461030 | 0.85 | HPGD (0.49) | GPR119HPGDUSP2SMN1; SMN2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484856-B1 | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS | REVOLUTION MEDICINES INC (US) | 2023-11-15 | — | — | EP | disclosed |
| WO-2021033153-A1 | PYRAZOLO[3,4-B]PYRAZINE SHP2 PHOSPHATASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2021-02-25 | — | — | WO | disclosed |
| WO-2018013597-A1 | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS | Revolution Medicines, Inc. (US) | 2018-01-18 | — | — | WO | disclosed |