Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20558279 | 0.85 | HSD11B1 (0.44) | HSD11B1TNFOPRD1OPRM1CCR1 | |
| SCHEMBL30373977 | 0.82 | HSD11B1 (0.42) | HSD11B1TNFOPRD1OPRM1CCR1 | |
| SCHEMBL625012 | 0.82 | HSD11B1 (0.42) | HSD11B1TNFOPRD1OPRM1CCR1 | |
| SCHEMBL55992 | 0.82 | HSD11B1 (0.42) | HSD11B1TNFOPRD1OPRM1CCR1 | |
| SCHEMBL30467212 | 0.82 | HSD11B1 (0.42) | HSD11B1TNFOPRD1OPRM1CCR1 | |
| SCHEMBL15822378 | 0.81 | HSD11B1 (0.42) | HSD11B1TNFOPRD1OPRM1CCR1 | |
| SCHEMBL3644735 | 0.81 | HSD11B1 (0.42) | HSD11B1TNFOPRD1OPRM1CCR1 | |
| SCHEMBL31441137 | 0.81 | HSD11B1 (0.42) | HSD11B1TNFOPRD1OPRM1CCR1 | |
| SCHEMBL21287848 | 0.80 | OPRM1 (0.49) | OPRD1OPRM1ALDH1A1CA12CA1 | |
| SCHEMBL14542590 | 0.78 | HSD11B1 (0.40) | HSD11B1TNFOPRD1OPRM1CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484856-B1 | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS | REVOLUTION MEDICINES INC (US) | 2023-11-15 | — | — | EP | disclosed |
| WO-2018013597-A1 | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS | Revolution Medicines, Inc. (US) | 2018-01-18 | — | — | WO | disclosed |