Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 9/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 8/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19785492 | 0.90 | CD274 (0.44) | KDRCD274PDCD1BTKALDH1A1 | |
| SCHEMBL19785826 | 0.84 | SUCNR1 (0.50) | KDRCD274PDCD1BTKALDH1A1 | |
| SCHEMBL19785953 | 0.84 | KDR (0.45) | KDRALDH1A1HTTKDM4ELMNA | |
| SCHEMBL19779430 | 0.80 | MEN1 (0.46) | CD274PDCD1BTKRAB9A | |
| SCHEMBL19779681 | 0.78 | CD274 (0.45) | CD274PDCD1BTKALDH1A1SUCNR1 | |
| SCHEMBL23244042 | 0.76 | PDCD1 (0.44) | CD274PDCD1BTKALDH1A1HTT | |
| SCHEMBL18979827 | 0.74 | CD274 (0.52) | CD274PDCD1ALDH1A1HTTKDM4E | |
| SCHEMBL18979842 | 0.74 | CD274 (0.53) | CD274PDCD1ALDH1A1NPC1RAB9A | |
| SCHEMBL19785837 | 0.73 | KDR (0.46) | KDRHTTKDM4ELMNANPC1 | |
| SCHEMBL18979737 | 0.73 | PDCD1 (0.52) | CD274PDCD1ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013789-A1 | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS | INCYTE CORPORATION (US) | 2018-01-18 | — | — | WO | disclosed |