Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19785837 | 0.90 | KDR (0.46) | KDRKDM4ERXFP1PARP1MEN1 | |
| SCHEMBL19785758 | 0.84 | KDR (0.43) | KDRKDM4ENPC1RAB9ALMNA | |
| SCHEMBL19779694 | 0.79 | ATM (0.42) | KDM4ERXFP1MEN1KMT2ANPC1 | |
| SCHEMBL19785841 | 0.75 | PDCD1 (0.46) | KDR | |
| SCHEMBL19785950 | 0.75 | TAS1R3 (0.45) | KDRKDM4ERXFP1MEN1KMT2A | |
| SCHEMBL19785492 | 0.73 | CD274 (0.44) | KDRKDM4ENPC1RAB9ALMNA | |
| SCHEMBL31354374 | 0.71 | PDCD1 (0.46) | MEN1KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL22659649 | 0.71 | CD274 (0.47) | ATM | |
| SCHEMBL19779555 | 0.70 | ATM (0.43) | KDM4ERXFP1MEN1KMT2ANPC1 | |
| SCHEMBL19785763 | 0.70 | KDR (0.37) | KDRRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013789-A1 | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS | INCYTE CORPORATION (US) | 2018-01-18 | — | — | WO | disclosed |