Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.45 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19785492 | 0.85 | CD274 (0.44) | SUCNR1KDRCD274PDCD1BTK | |
| SCHEMBL19785758 | 0.84 | KDR (0.43) | SUCNR1KDRCD274PDCD1BTK | |
| SCHEMBL19780010 | 0.78 | MEN1 (0.65) | SUCNR1CD274PDCD1BTKALDH1A1 | |
| SCHEMBL19785759 | 0.75 | CD274 (0.56) | CD274PDCD1ALDH1A1KDM4EMAPT | |
| SCHEMBL19785761 | 0.74 | CD274 (0.68) | CD274PDCD1 | |
| SCHEMBL13053955 | 0.74 | NPC1 (0.62) | CD274PDCD1BTKALDH1A1HTT | |
| SCHEMBL29516927 | 0.71 | NPC1 (0.70) | CD274PDCD1ALDH1A1KDM4EMAPT | |
| SCHEMBL29788136 | 0.71 | KDM4E (0.55) | CD274PDCD1BTKALDH1A1HTT | |
| Toluene SCHEMBL2285073 | 0.70 | DYRK1A (0.75) | DYRK1AALDH1A1KDM4E | |
| SCHEMBL18979851 | 0.70 | PDCD1 (0.53) | CD274PDCD1ALDH1A1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013789-A1 | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS | INCYTE CORPORATION (US) | 2018-01-18 | — | — | WO | disclosed |