Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 18/20 | 0.51 |
| ▸ | DHODH | Q02127 | 16/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22383772 | 0.90 | RORC (0.53) | RORCDHODHL3MBTL1 | |
| SCHEMBL19785934 | 0.89 | RORC (0.47) | RORCDHODHL3MBTL1 | |
| SCHEMBL22383778 | 0.86 | RORC (0.49) | RORCDHODHL3MBTL1 | |
| SCHEMBL22383765 | 0.86 | RORC (0.46) | RORCDHODH | |
| SCHEMBL22383754 | 0.83 | RORC (0.47) | RORCDHODHL3MBTL1 | |
| SCHEMBL19785619 | 0.82 | SMN1; SMN2 (0.40) | RORCL3MBTL1 | |
| SCHEMBL22383768 | 0.82 | FASN (0.36) | RORCDHODHL3MBTL1 | |
| SCHEMBL22383769 | 0.82 | SMN1; SMN2 (0.39) | L3MBTL1 | |
| SCHEMBL22383763 | 0.80 | RORC (0.48) | RORCDHODH | |
| SCHEMBL19785912 | 0.79 | FASN (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484880-B1 | HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA AS (DK) | 2020-09-02 | — | — | EP | disclosed |
| WO-2018011201-A1 | HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA A/S (DK) | 2018-01-18 | — | — | WO | disclosed |