Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 10/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | FASN | P49327 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28720859 | 0.92 | RORC (0.36) | RORCKCNH2CCR1PTGDR2 | |
| SCHEMBL21368605 | 0.92 | RORC (0.36) | RORCKCNH2CCR1PTGDR2 | |
| SCHEMBL29613318 | 0.92 | RORC (0.36) | RORCKCNH2CCR1PTGDR2 | |
| SCHEMBL29613311 | 0.92 | RORC (0.36) | RORCKCNH2CCR1PTGDR2 | |
| SCHEMBL21368604 | 0.92 | RORC (0.36) | RORCKCNH2CCR1PTGDR2 | |
| SCHEMBL21368883 | 0.91 | RORC (0.38) | RORCKCNH2CCR1PTGDR2MGLL | |
| SCHEMBL29613289 | 0.91 | RORC (0.38) | RORCKCNH2CCR1PTGDR2MGLL | |
| SCHEMBL21368750 | 0.91 | KCNH2 (0.36) | RORCKCNH2FASNCCR1PTGDR2 | |
| SCHEMBL29613296 | 0.91 | KCNH2 (0.36) | RORCKCNH2FASNCCR1PTGDR2 | |
| SCHEMBL28722678 | 0.89 | RORC (0.36) | RORCKCNH2CCR1PTGDR2MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484880-B1 | HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA AS (DK) | 2020-09-02 | — | — | EP | disclosed |
| WO-2018011201-A1 | HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA A/S (DK) | 2018-01-18 | — | — | WO | disclosed |