SCHEMBL19786271

SCHEMBL19786271

COc1ccc(CN(CCCn2ccnc2)Cc2ccc(OC)c(OC)c2)cc1OC

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
QPCT Q16769 14/20 0.58
TP53 P04637 1/20 0.54
CYP1A2 P05177 1/20 0.54
CYP3A4 P08684 1/20 0.54
CYP2D6 P10635 1/20 0.54
CYP2C9 P11712 1/20 0.54
TSHR P16473 1/20 0.54
NFKB1 P19838 1/20 0.54
CYP2C19 P33261 1/20 0.54
MTOR P42345 1/20 0.54
RAB9A P51151 1/20 0.54
HIF1A Q16665 1/20 0.54
MEN1 O00255 1/20 0.53
GMNN O75496 1/20 0.53
LMNA P02545 1/20 0.53
MAPT P10636 1/20 0.53
BLM P54132 1/20 0.53
PMP22 Q01453 1/20 0.53
KMT2A Q03164 1/20 0.53
TDP1 Q9NUW8 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19766927 0.94 QPCT (0.53) QPCTTP53CYP1A2CYP3A4CYP2D6
SCHEMBL19766926 0.89 QPCT (0.59) QPCTTP53CYP1A2CYP3A4CYP2D6
SCHEMBL4539675 0.83 TP53 (0.69) QPCTTP53CYP1A2CYP3A4CYP2D6
SCHEMBL12845734 0.77 TP53 (0.60) QPCTTP53CYP1A2CYP3A4CYP2D6
SCHEMBL21592271 0.74 CYP11B1 (0.48) QPCTRAB9AMAPTALDH1A1NPC1
SCHEMBL76179 0.74 QPCT (1.00) QPCTQPCTLALDH1A1
SCHEMBL16350670 0.74 QPCT (0.77) QPCTTSHRMEN1MAPTKMT2A
SCHEMBL5757028 0.72 TSHR (0.58) QPCTTP53CYP1A2CYP3A4CYP2D6
SCHEMBL14465644 0.72 MEN1 (0.60) QPCTTP53CYP1A2CYP3A4CYP2D6
SCHEMBL4820581 0.72 POLB (0.45) QPCTLMNAALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109476803-B Amine compositions useful for making polyurethane foams 赢创运营有限公司 2022-04-12 CN disclosed
US-11021561-B2 Amine composition useful for making polyurethane foam EVONIK OPERATIONS GMBH (DE) 2021-06-01 US disclosed
WO-2018013590-A1 AMINE COMPOSITION USEFUL FOR MAKING POLYURETHANE FOAM EVONIK DEGUSSA GMBH (DE) 2018-01-18 WO disclosed