SCHEMBL5757028

SCHEMBL5757028

COc1cc(CCCn2ccnc2)ccc1O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.58
TP53 P04637 1/20 0.58
CYP1A2 P05177 1/20 0.58
CYP3A4 P08684 1/20 0.58
CYP2D6 P10635 1/20 0.58
CYP2C9 P11712 1/20 0.58
NFKB1 P19838 1/20 0.58
CYP2C19 P33261 1/20 0.58
MTOR P42345 1/20 0.58
RAB9A P51151 1/20 0.58
HIF1A Q16665 1/20 0.58
QPCT Q16769 3/20 0.57
LMNA P02545 2/20 0.57
MEN1 O00255 1/20 0.57
GMNN O75496 1/20 0.57
MAPT P10636 1/20 0.57
BLM P54132 1/20 0.57
PMP22 Q01453 1/20 0.57
KMT2A Q03164 1/20 0.57
TDP1 Q9NUW8 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4539675 0.88 TP53 (0.69) TSHRTP53CYP1A2CYP3A4CYP2D6
SCHEMBL10942842 0.84 ALDH1A1 (0.65) CYP1A2CYP2C9MEN1KMT2ACYP19A1
SCHEMBL5759263 0.80 CYP19A1 (0.57) CYP19A1TBXAS1HMOX1
SCHEMBL5758544 0.79 CYP1A2 (0.58) TSHRTP53CYP1A2CYP3A4CYP2D6
SCHEMBL10508142 0.78 MEN1 (0.69) TSHRTP53CYP1A2CYP3A4CYP2D6
SCHEMBL5760176 0.77 TAAR1 (0.51) TSHRCYP1A2CYP2C9LMNAMEN1
SCHEMBL9281549 0.77 TAAR1 (0.76) TSHRCYP3A4NFKB1LMNATDP1
SCHEMBL5072123 0.77 TAAR1 (0.76) TSHRCYP1A2CYP3A4CYP2C9NFKB1
SCHEMBL2749075 0.76 CYP19A1 (0.71) CYP19A1TBXAS1HMOX1
SCHEMBL5045082 0.74 MEN1 (0.68) TSHRTP53CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1270571-B1 Heterocyclic compounds, their production and use TAKEDA PHARMACEUTICAL (JP) 2006-09-06 EP disclosed
EP-1270571-A1 Heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2003-01-02 EP disclosed
US-6211215-B1 AROMATIC HETEROCYCLIC COMPOUND WITH AZOLE COMPOUND TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-04-03 US disclosed
EP-0912562-A1 HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1999-05-06 EP disclosed
WO-1998003505-A2 HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-01-29 WO disclosed